{"created":"2024-10-24T00:30:21.104328+00:00","id":2000981,"links":{},"metadata":{"_buckets":{"deposit":"43fe14ec-11cf-476f-a0cd-235db583b626"},"_deposit":{"created_by":15,"id":"2000981","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000981"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000981","sets":["631:636:1728958087061"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-26","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"特発性肺線維症（IPF）は、慢性進行性に高度の線維化と肺胞構築の改変を呈する原因不明の致死的な肺疾患である。 近年、細菌叢がIPFの病態に関与することが報告されているが詳細な機序は不明である。我々は以前に肺線維症マウスの肺組織から細菌由来の細胞死誘導ペプチドであるcorisinを発見した。本研究ではcorisinの活性を抑制するモノクローナル抗体を作製し、複数の肺線維症マウスモデルに投与して病態抑制効果を検討した。その結果、抗corisin抗体の投与により肺の炎症や線維化、肺胞上皮細胞の細胞死が抑制された。本研究結果から、corisinが肺線維症の病態進行や急性増悪関与することが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. We recently identified corisin, a proapoptotic peptide that triggers acute exacerbation of pulmonary fibrosis. In this study, we prepared a monoclonal antibody that suppresses the activity of corisin and verified its effect on a pulmonary fibrosis mouse model. We have shown that an anticorisin monoclonal antibody ameliorates inflammation, fibrosis and apoptosis of alveolar epithelial cells in the human transforming growth factorβ1 model and the bleomycin model. These results underscore the role of corisin in the pathogenesis of acute exacerbation of pulmonary fibrosis and provide a novel approach to treating this incurable disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2021年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21K16116","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安間, 太郎","creatorNameLang":"ja"},{"creatorName":"Yasuma, Taro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-24"}],"filename":"2024RP0071.pdf","filesize":[{"value":"980 KB"}],"format":"application/pdf","url":{"label":"2024RP0071.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000981/files/2024RP0071.pdf"},"version_id":"930e7f8e-b9d3-4d6e-9503-2c7da07bf76c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"特発性肺線維症","subitem_subject_scheme":"Other"},{"subitem_subject":"細菌叢","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細菌由来アポトーシス促進ペプチドを標的とした特発性肺線維症治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細菌由来アポトーシス促進ペプチドを標的とした特発性肺線維症治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of treatment for idiopathic pulmonary fibrosis targeting bacterial-derived apoptosis-promoting peptides","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958087061"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-24"},"publish_date":"2024-10-24","publish_status":"0","recid":"2000981","relation_version_is_last":true,"title":["細菌由来アポトーシス促進ペプチドを標的とした特発性肺線維症治療法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-24T00:40:24.336637+00:00"}