{"created":"2024-10-24T00:48:56.342724+00:00","id":2000982,"links":{},"metadata":{"_buckets":{"deposit":"b2fa8bda-038d-4a85-b5fe-d1bf36de9219"},"_deposit":{"created_by":15,"id":"2000982","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000982"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000982","sets":["631:636:1728958087061"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-17","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細菌由来ペプチドであるcorisinを投与した腎線維症モデルマウスでは対象群と比較して尿中アルブミン排泄量が増加し、病理検査では糸球体及び尿細管間質線維化の進行が示唆された。これらの結果は、腎線維症モデルマウスおいて corisinが腎線維化を促進していることを示唆する。また、in vitro実験ではcorisinおよびcorisin-likeペプチドによりPodocyteおよびCaki-2細胞にアポトーシスが誘導され、TGF-βとcorisinの共刺激ではアポトーシスの誘導が増強された。これらの結果はcorisinが腎臓由来の細胞のアポトーシスの誘導に関与していることを示唆する。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In mice treated with the microbiota-derived peptide corisin, urinary albumin excretion was increased in the renal fibrosis model compared to the control group, and pathological examination suggested progressive glomerular and tubulointerstitial fibrosis. These results suggest that corisin promotes renal fibrosis in the mouse model of renal fibrosis. In vitro experiments also showed that corisin and corisin-like peptides induced apoptosis in podocyte and Caki-2 cells, and co-stimulation with TGF-β and corisin enhanced apoptosis induction. These results suggest that corisin is involved in the induction of apoptosis in kidney-derived cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2021年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21K16160","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西濱, 康太","creatorNameLang":"ja"},{"creatorName":"Nishihama, Kota","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-24"}],"filename":"2024RP0072.pdf","filesize":[{"value":"996 KB"}],"format":"application/pdf","url":{"label":"2024RP0072.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000982/files/2024RP0072.pdf"},"version_id":"bdb2bbd5-be7c-4b8d-90a5-3574eb6fc36c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"腎線維化","subitem_subject_scheme":"Other"},{"subitem_subject":"細菌叢","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腎・尿路細菌叢および関連ペプチドが腎線維化に与える影響の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腎・尿路細菌叢および関連ペプチドが腎線維化に与える影響の解明","subitem_title_language":"ja"},{"subitem_title":"The role of renal and urethral flora and related peptides in renal fibrosis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958087061"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-24"},"publish_date":"2024-10-24","publish_status":"0","recid":"2000982","relation_version_is_last":true,"title":["腎・尿路細菌叢および関連ペプチドが腎線維化に与える影響の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-24T00:55:09.136811+00:00"}