{"created":"2024-10-24T00:59:46.395021+00:00","id":2000983,"links":{},"metadata":{"_buckets":{"deposit":"6b01bf75-2731-4435-940a-0b2ec607a8d0"},"_deposit":{"created_by":15,"id":"2000983","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000983"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000983","sets":["631:636:1728958087061"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"小児の抗菌薬試験は、倫理的、実践的、および経済的な考慮事項のためにほとんど実施されておらず、小児患者を対象とした各抗菌薬のPharmacokinetics/Pharmacodynamics(PK/PD)パラメータおよび至適投与法を明らかにすることは臨床上重要である。\n本研究では、小児患者において、バンコマイシンの血中トラフ濃度10-15 mg/Lが最適なトラフ濃度であること、アミカシンの最小血中濃度が10 mg/Lを超えないことを明らかにした。また、乳児において、7.5 mg/kg/日未満のゲンタマイシン投与量が効果的で安全なレジメンであることを示した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Few studies for antibiotic therapy in pediatric patients have been conducted due to ethical, practical, and economic considerations, and thus, establishment of pharmacokinetics-pharmacodynamics parameters and optimal dosage regimens are clinically important. In this present study, it has been revealed that vancomycin trough level of 10-15 mg/L and amikacin minimum concentration of below 10 mg/L are superior benefit for pediatric patients. Moreover, gentamicin dosages below 7.5 mg/kg/day are effective and safe for use in infant patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2021年度～2022年度科学研究費補助金(研究活動スタート支援)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21K20714","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加藤, 秀雄","creatorNameLang":"ja"},{"creatorName":"Kato, Hideo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-24"}],"filename":"2024RP0073.pdf","filesize":[{"value":"98 KB"}],"format":"application/pdf","url":{"label":"2024RP0073.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000983/files/2024RP0073.pdf"},"version_id":"3767961f-d773-481e-acb1-f5037357aa66"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"小児","subitem_subject_scheme":"Other"},{"subitem_subject":"抗菌薬投与設計","subitem_subject_scheme":"Other"},{"subitem_subject":"PK/PDパラメータ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"小児患者の抗菌薬初期投与設計のアルゴリズムおよびノモグラムの作成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小児患者の抗菌薬初期投与設計のアルゴリズムおよびノモグラムの作成","subitem_title_language":"ja"},{"subitem_title":"Creations of algorithm and nomogram for initial dosing regimen of antibiotics in pediatric patients","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958087061"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-24"},"publish_date":"2024-10-24","publish_status":"0","recid":"2000983","relation_version_is_last":true,"title":["小児患者の抗菌薬初期投与設計のアルゴリズムおよびノモグラムの作成"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-24T01:07:05.283868+00:00"}