{"created":"2024-10-24T01:29:02.446878+00:00","id":2000985,"links":{},"metadata":{"_buckets":{"deposit":"c94a824c-576a-4e73-9805-3a6a896571cd"},"_deposit":{"created_by":15,"id":"2000985","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000985"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000985","sets":["631:636:1728958087061"]},"author_link":[],"control_number":"2000985","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-18","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"心臓特異的MYPT2KOマウス（≒ミオシン軽鎖(MLC)ホスファターゼKOマウス）は、MYPT2-floxマウスとαMHC MerCreMerマウスとの交配で作成した。心臓MYPT2KOマウスでは心筋MLCホスファターゼの触媒サブユニットPP1が低下した。心臓特異的MYPT2KOマウスは、明らかな心機能の変化や形態変化を認めなかった。アルドステロン(Ald)投与の心不全モデルでは、心臓MYPT2KOマウスは野生型に比較し、心臓の収縮能および拡張能が保たれ、CTGFが低下し、心臓の線維化が抑制されていた。HL-1細胞でMYPT2をノックダウンすると、Ald刺激によるCTGF増加が抑制された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"To examine the effect of deletion of myosin light chain phosphatase (MLCP) in heart, we developed cardiomyocyte specific deletion knockout mice of MYPT2, myosin phosphatase target subunit 2 (c-MYPT2-/- mice). After aldosterone treatment, c-MYPT2-/- mice could preserve cardiac systolic and diastolic function better than wild-type mice. These results were accompanied with decreased collagen tissue growth factor (CTGF) and decreased cardiac fibrosis. Both MYPT2 and CTGF were increased in HL-1 cardiomyocytes after treatment of aldosterone (Ald). After knockdown of MYPT2, CTGF induction was prevented in HL-1 cells treated with Ald.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2022年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K08578","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡本, 隆二","creatorNameLang":"ja"},{"creatorName":"Okamoto, Ryuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"伊藤, 正明","creatorNameLang":"ja"},{"creatorName":"Ito, Masaaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"土肥, 薫","creatorNameLang":"ja"},{"creatorName":"Dohi, Kaoru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-24"}],"filename":"2024RP0075.pdf","filesize":[{"value":"208 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2024RP0075.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000985/files/2024RP0075.pdf"},"version_id":"92d64a91-dc6e-4df0-8286-1139637b2e1b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"心肥大","subitem_subject_scheme":"Other"},{"subitem_subject":"心不全","subitem_subject_scheme":"Other"},{"subitem_subject":"ねじれ運動","subitem_subject_scheme":"Other"},{"subitem_subject":"ミオシン軽鎖","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心肥大及び心不全発症における、ねじれ運動制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心肥大及び心不全発症における、ねじれ運動制御機構の解明","subitem_title_language":"ja"},{"subitem_title":"MLC phosphatase plays an important role in cardiac function and fibrosis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958087061"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-24"},"publish_date":"2024-10-24","publish_status":"0","recid":"2000985","relation_version_is_last":true,"title":["心肥大及び心不全発症における、ねじれ運動制御機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-24T01:39:33.487749+00:00"}