{"created":"2024-10-24T02:16:03.690509+00:00","id":2000987,"links":{},"metadata":{"_buckets":{"deposit":"a059d537-e082-48ee-b5de-683f587c2531"},"_deposit":{"created_by":15,"id":"2000987","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000987"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000987","sets":["631:636:1728958087061"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-07","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は、ナノマテリアル 、特に超常磁性体酸化鉄(SPIO)を利用した治療法の提案を背景に、泌尿器腫瘍（前立腺癌、尿路上皮癌、腎癌）細胞などの生体膜（細胞膜）を利用し、ナノ粒子をコアとした診断・治療用新規ナノキャリアの作製を目指した。（１）破砕した細胞膜の自己集合を利用したナノキャリアの合成、（２）細胞本来が有する生理学的プロセスを利用した方法（ナノ粒子曝露により細胞に取り込まれたナノ粒子がexosomeという形で排出）を試みた。手法が困難であるが、（１）の方法で細胞膜が付着したナノ粒子の作製に成功し、細胞内への取り入れ増大の可能性を見出した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In the background of a proposal for a therapeutic method using nanomaterials, especially superparamagnetic iron oxide (SPIO), we aimed to fabricate novel nanocarriers for diagnosis and treatment with nanoparticles as the core by utilizing biological membranes (cell membranes) of urological tumor cells (prostate cancer, urothelial carcinoma, renal cancer) and other cells. We attempted (1) synthesis of nanocarriers using self-assembly of ruptured cell membranes and (2) method using physiological processes inherent to cells (nanoparticles taken into cells by exposure to nanoparticles are discharged in the form of exosomes). Although the methods being difficult, we succeeded in producing nanoparticles covered by cell membranes and found the possibility of increasing cellular uptake.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2022年度科学研究費補助金(挑戦的研究(萌芽))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K22684","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, 昭伸","creatorNameLang":"ja"},{"creatorName":"Hayashi, Akinobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"林, 幸壱朗","creatorNameLang":"ja"},{"creatorName":"Hayashi, Koichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡邉, 昌俊","creatorNameLang":"ja"},{"creatorName":"Watanabe, Masatoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"石井, 健一朗","creatorNameLang":"ja"},{"creatorName":"Ishii, Kenichiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-24"}],"filename":"2024RP0077.pdf","filesize":[{"value":"1 MB"}],"format":"application/pdf","url":{"label":"2024RP0077.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000987/files/2024RP0077.pdf"},"version_id":"95afafd6-d9ba-46bf-ba43-515f57305497"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"ナノ粒子","subitem_subject_scheme":"Other"},{"subitem_subject":"自己集合","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"泌尿器腫瘍の診断・治療のための生体膜修飾で拓くナノキャリアのプラットホーム作製","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"泌尿器腫瘍の診断・治療のための生体膜修飾で拓くナノキャリアのプラットホーム作製","subitem_title_language":"ja"},{"subitem_title":"Establishment of nanocarrier platform by cell membrane modification for diagnosis and treatment of urological cancers","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958087061"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-24"},"publish_date":"2024-10-24","publish_status":"0","recid":"2000987","relation_version_is_last":true,"title":["泌尿器腫瘍の診断・治療のための生体膜修飾で拓くナノキャリアのプラットホーム作製"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-24T02:24:53.133643+00:00"}