{"created":"2023-06-19T11:38:04.189784+00:00","id":5628,"links":{},"metadata":{"_buckets":{"deposit":"2d80b28a-96b1-46fa-a1e8-cbf6bb369dfc"},"_deposit":{"created_by":13,"id":"5628","owners":[13],"pid":{"revision_id":0,"type":"depid","value":"5628"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00005628","sets":["420:421:422:431"]},"author_link":["12066","12067","12068"],"control_number":"5628","item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1985-10-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"180","bibliographicPageStart":"175","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"三重大学水産学部研究報告 = Bulletin of the Faculty of Fisheries, Mie University"}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ミロキサシンを養殖プリに強制投与した場合，体内残留物として intact  なミロキサシン以外に，その代謝物であるM－1が，用いたすべての組織に検出された（上野ら，1985）。そこで，本研究ではミロキサシンおよびM－1の各種菌株に対する抗菌性，ミロキサシンの飼料中での安定性および養殖ブリにおけるミロキサシンおよぴM－1の組織内濃度およびそれらのダルクロン酸抱合体の存在について検討した。","subitem_description_type":"Abstract"},{"subitem_description":"The present work was undertaken to investigate the metabolites of miloxacin,5,8-dihydro-5-methoxy-8-oxo-2H-1,3-dioxolo(4,5-g) quinoline-7-carboxylic acid, in the yellowtail, Serioa quinqueradiata, and their antibacterial activity. At 2 hours after  oral administration at 40 mg/kg, high concentrations of intact miloxacin were observed in the kidney,bile and spleen while those of the metabolite,M-1,8,5-dihydro-8-oxo-2 H-1,3-dioxolo (4,5-g)quinoline-7-carboxylic acid, were in the kidney and spleen of yellowtail. The glucuronide of miloxacin was found in the muscle, kidny, bile and spleen(not detected in the blood and liver) as the minor metabolite, but that of M-1 was in the blood and liver as the major one. The activity of miloxacin and M-1 against bacteria was examined in vitro. Three strains were used; Aeromonas liquefacience and 2 strains of Vibrio sp isolated from fish. Miloxacin and M-1 were more active against Aeromonas, and the former was more active against Aeromonas and Vibriosthan the latter.","subitem_description_type":"Abstract"}]},"item_4_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学水産学部"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0287-5772","subitem_source_identifier_type":"PISSN"}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN0023428X","subitem_source_identifier_type":"NCID"}]},"item_4_subject_16":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"464","subitem_subject_scheme":"NDC"}]},"item_4_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Study of quality in fish and shellfish as food - III : Metabolites of miloxacin in cultured yellowtail and their antibacterial activity"}]},"item_4_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Agropedia提供データ"}]},"item_4_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper / 紀要論文"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上野, 隆二","creatorNameLang":"ja"},{"creatorName":"Ueno, Ryuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"奥村, 雅人","creatorNameLang":"ja"},{"creatorName":"Okumura, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"堀口, 吉重","creatorNameLang":"ja"},{"creatorName":"Horiguchi, Yoshishige","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"AN0023428X0001218.pdf","filesize":[{"value":"255.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN0023428X0001218.pdf","url":"https://mie-u.repo.nii.ac.jp/record/5628/files/AN0023428X0001218.pdf"},"version_id":"f15b4783-a18d-4777-9b20-1cff963db399"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"metabolites","subitem_subject_scheme":"Other"},{"subitem_subject":"miloxacin","subitem_subject_scheme":"Other"},{"subitem_subject":"yellowtail","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"食品としての魚介類の品質に関する研究 - III : 養殖ブリにおけるミロキサンシンの代謝物およびその抗菌性について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食品としての魚介類の品質に関する研究 - III : 養殖ブリにおけるミロキサンシンの代謝物およびその抗菌性について","subitem_title_language":"ja"}]},"item_type_id":"4","owner":"13","path":["431"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-06-19"},"publish_date":"2007-06-19","publish_status":"0","recid":"5628","relation_version_is_last":true,"title":["食品としての魚介類の品質に関する研究 - III : 養殖ブリにおけるミロキサンシンの代謝物およびその抗菌性について"],"weko_creator_id":"13","weko_shared_id":-1},"updated":"2023-10-16T01:17:28.131612+00:00"}