{"created":"2023-06-19T11:38:13.510174+00:00","id":5842,"links":{},"metadata":{"_buckets":{"deposit":"584b4582-5dde-4983-83b8-6cab7a653dc9"},"_deposit":{"created_by":13,"id":"5842","owners":[13],"pid":{"revision_id":0,"type":"depid","value":"5842"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00005842","sets":["420:421:443:464"]},"author_link":["13124","13125","13126","13127"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-01-05","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"85","bibliographicPageStart":"73","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"三重大学生物資源学部紀要 = The bulletin of the Faculty of Bioresources, Mie University"}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the effects of poly (ADP - ribose) polymerase (PARP) inhibitors and\nNAD on the apoptosis induced by Actinomycin D in human promyelomonocytic\nleukemia cells HL - 60. As the results, the apoptosis was repressed by various PARP\ninhibitors especially by 3 - aminobenzamide ( 3 – ABA ), which is a potent inhibitor forPARP reaction. On the contrary, 3-ABA was no more inhibitory in a cell-free apoptosissystem. This result suggests that the inhibitory effect of 3 - ABA is effective only before apoptotic cytosol is made up in the cells, i.e., in an early stage of the apoptotic process. But NAD inhibited the apoptosis in the same system depending on NAD concentration. So the inhibition of apoptosis by NAD may be concerned in a later step of apoptosis.","subitem_description_type":"Abstract"}]},"item_4_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学生物資源学部"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-0471","subitem_source_identifier_type":"PISSN"}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10073846","subitem_source_identifier_type":"NCID"}]},"item_4_subject_16":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_4_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"ヒト白血病細胞HL-60においてアクチノマイシンDで誘導されるアポトーシスに及ぼすポリ(ADP-リボース)ポリメラーゼ阻害剤とNADの影響"}]},"item_4_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper / 紀要論文"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"緒方, 進","creatorNameLang":"ja"},{"creatorName":"Ogata, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野中, 洋志","creatorNameLang":"ja"},{"creatorName":"Nonaka, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"奥村, 克純","creatorNameLang":"ja"},{"creatorName":"Okumura, Katsuzumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田口, 寛","creatorNameLang":"ja"},{"creatorName":"Taguchi, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"50C12504.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"50C12504.pdf","url":"https://mie-u.repo.nii.ac.jp/record/5842/files/50C12504.pdf"},"version_id":"e709194e-1bcb-42b8-a003-0c1dbbdfa9a6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"poly (ADP-ribose) polymerase","subitem_subject_scheme":"Other"},{"subitem_subject":"NAD","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Actinomycin D","subitem_subject_scheme":"Other"},{"subitem_subject":"HL-60","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of poly (ADP-ribose) polymerase inhibitors and NAD on the apoptosis induced by actinomycin D in human leukemia cells HL-60","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of poly (ADP-ribose) polymerase inhibitors and NAD on the apoptosis induced by actinomycin D in human leukemia cells HL-60","subitem_title_language":"en"}]},"item_type_id":"4","owner":"13","path":["464"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-03-18"},"publish_date":"2010-03-18","publish_status":"0","recid":"5842","relation_version_is_last":true,"title":["Effects of poly (ADP-ribose) polymerase inhibitors and NAD on the apoptosis induced by actinomycin D in human leukemia cells HL-60"],"weko_creator_id":"13","weko_shared_id":-1},"updated":"2023-10-12T07:23:58.106163+00:00"}