@article{oai:mie-u.repo.nii.ac.jp:00006067,
 author = {Komiya, Takashi and 小宮, 孝志 and Hibasami, Hiroshige and 樋廻, 博重},
 journal = {三重大学生物資源学部附属農場研究報告 = The bulletin of the Experimental Farm, Faculty of Bioresources, Mie University},
 month = {Mar},
 note = {application/pdf, The exposure of human lymphoid leukemia Molt 4B cells to sodium 1-monolinolenin（SML）which was isolated from the leaves of Italian ryegrass Lolium multiflorum Lam）and identified by Mass, and H-and C-NMR, led to both growth inhibition and induction of programmed cell death（apoptosis）. Morphological change showing apoptotic bodies was observed in the Molt 4B cells treated with SML. The fragmentation by SML of DNA to oligonucleosomal-sized fragments, that is a characteristic of apoptosis, was observed to be both concentration-and time-dependent. These findings suggest that growth inhibition by SML of Molt 4B cells results from the induction of apoptosis in the cells., イタリアンライグラス(Lolium multiflorum Lam)から単離し，MS，H-NMRやC-NMRにより構造決定した sodium 1- monolinolenin (SML)はヒト白血病Molt 4B 細胞の増殖を阻害し，且つプログラム細胞死(アポトーシス)を誘導した。SMLで処理したこの細胞の形態を顕微鏡観察したところ，アポトーシス小体が認められた。この処理細胞から抽出したDNAはオリゴヌクレオゾームの単位で断片化され，その変化は濃度と時間に依存的であった。},
 pages = {1--12},
 title = {Sodium 1- monolinolenin isolated from Italian ryegrass (Lolium multiflorum Lam.) induces apoptosis in human lymphoid leukemia Molt 4B cells},
 volume = {13},
 year = {2002}
}