{"created":"2023-06-19T11:38:26.329772+00:00","id":6132,"links":{},"metadata":{"_buckets":{"deposit":"a6466082-fba4-46fe-8f15-08a95ba7b564"},"_deposit":{"created_by":13,"id":"6132","owners":[13],"pid":{"revision_id":0,"type":"depid","value":"6132"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00006132","sets":["420:421:481:484"]},"author_link":["13907","13908","13909"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"58","bibliographicPageStart":"53","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"三重大学大学院生物資源学研究科紀要"}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have been investigating the effective uses of prevention and treatment of life style-related disease by nicotinic acid and its related compounds. We investigated differentiation- inducing abilities of 23 nicotinic acid-related compounds in two human leukemia cell lines. In this study, We used human myeroidleukemia cells, HL-60 and human erythroleukemia cells, K562. As the results, differentiation to granulocyte ?like cells was induced by nicotinamide, nicotinamide N-oxide, and isonicotinic acid in HL-60 cells. In K562 cells, differentiation to erythroid-like cells was induced by nicotinic acid and isonicotinic acid.","subitem_description_type":"Abstract"},{"subitem_description":"我々は，ニコチン酸およびその関連化合物による，生活習慣病の予防や治療への有効利用に関する検討を行ってきた。そして，23種類のニコチン酸関連化合物を用いて，2種類の白血病細胞株に対する分化誘導効果について検討を行った。今回の検討では， ヒト急性白血病細胞HL-60とヒト慢性白血病細胞K562を用いた。その結果，HL-60においては，ニコチンアミド，ニコチンアミドN－オキシド，イソニコチン酸において顆粒球様細胞への分化誘導効果が認められた。また，K562においては，ニコチン酸とイソニコチン酸において，赤血球様細胞への分化誘導が認められた。","subitem_description_type":"Abstract"}]},"item_4_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学大学院生物資源学研究科"}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12234310","subitem_source_identifier_type":"NCID"}]},"item_4_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines"}]},"item_4_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper / 紀要論文"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"緒方, 進","creatorNameLang":"ja"},{"creatorName":"OGATA, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井田, 智恵利","creatorNameLang":"ja"},{"creatorName":"IDA, Chieri","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田口, 寛","creatorNameLang":"ja"},{"creatorName":"TAGUCHI, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"50C17812.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"50C17812.pdf","url":"https://mie-u.repo.nii.ac.jp/record/6132/files/50C17812.pdf"},"version_id":"8b76aa4a-7da4-43e7-a770-04a1048afb17"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"nicotinic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"nicotinamide","subitem_subject_scheme":"Other"},{"subitem_subject":"human leukemia cell","subitem_subject_scheme":"Other"},{"subitem_subject":"NAD","subitem_subject_scheme":"Other"},{"subitem_subject":"isonicotinic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"differentiation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ニコチン酸，ニコチンアミドおよびイソニコチン酸のヒ卜白血病細胞に対する分化誘導","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ニコチン酸，ニコチンアミドおよびイソニコチン酸のヒ卜白血病細胞に対する分化誘導","subitem_title_language":"ja"}]},"item_type_id":"4","owner":"13","path":["484"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-11-01"},"publish_date":"2016-11-01","publish_status":"0","recid":"6132","relation_version_is_last":true,"title":["ニコチン酸，ニコチンアミドおよびイソニコチン酸のヒ卜白血病細胞に対する分化誘導"],"weko_creator_id":"13","weko_shared_id":-1},"updated":"2023-10-10T04:35:35.513850+00:00"}