{"created":"2023-06-19T11:39:21.883687+00:00","id":7388,"links":{},"metadata":{"_buckets":{"deposit":"cdabbe40-f1e7-4e59-bfb5-023322389589"},"_deposit":{"created_by":15,"id":"7388","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7388"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007388","sets":["143:602:1692661270986"]},"author_link":["17357"],"control_number":"7388","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-05-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"69","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科研費報告書"}]}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肥満や糖・脂質代謝異常、高血圧などの動脈硬化危険因子は同一個人に集簇して存在しやすいことが明らかにされており、近年、メタボリックシンドローム (MS)といった概念で整理されつつある。本研究は日本人肥満小児におけるMSの実態を把握するため、MSの発症頻度や、それに対する性や年齢、肥満度の影響を検討した。対象は平均年齢9.1歳の肥満小児247名(男児151名、女児96名、平均肥満度45.7%)であり、空腹時採血により中性脂肪、HDLコレステロール、血糖値、インスリン値、尿酸値、GPTの定量を行った。また、血圧測定、ならびに腹部CT撮影を行い、腹部脂肪分布の検討を行った。その後、2005年に発表されたMSの診断基準と小児適正体格検討委員会の提唱しているカットオフ値を用いMSの判定を行った。日本人小児におけるMSの発症頻度は、標準体重児で0.9〜1.4%(原ら2005)と報告されているのに対し、肥満小児では14.6%と高値を示した。MSの発症頻度は全体として性差は認められなかったが、肥満度が高くなるほど、また年齢が上昇するほど高頻度に出現することが示唆された。脂質代謝や血圧では異常値の頻度に性差が認められないにもかかわらず、内臓脂肪の異常値は男児に(オッズ比女児に対し2.7倍)、また、インスリン値の異常は女児に(オッズ比男児に対し2.8倍)高頻度であり、小児期であっても性によりMSを形成する基盤が異なる可能性が示唆された。尿酸値やALTなども肥満小児(特に男児)において高頻度に異常値が認められたことから、このまま肥満が放置された場合、動脈硬化性疾患のみならず痛風や脂肪肝などの疾患を発症する可能性が示唆された。現在、MSを有する肥満小児を対象とした食事療法、運動療法を実施中であり、次年度はこれらの結果も踏まえて現状および対策を整理する予定である。","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成17年度～平成18年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"},{"subitem_description":"津","subitem_description_type":"Other"},{"subitem_description":"69","subitem_description_type":"Other"}]},"item_8_description_62":{"attribute_name":"目次","attribute_value_mlt":[{"subitem_description":"肥満小児におけるメタボリックシンドロームの現状とその改善 (<特集>メタボリックシンドローム改善の取り組み)","subitem_description_type":"Other"},{"subitem_description":"小児肥満とその問題点(<連載>肥満の評価と予防のためのエビデンス4)","subitem_description_type":"Other"},{"subitem_description":"肥満小児のインスリン抵抗性獲得における内臓脂肪の影響","subitem_description_type":"Other"},{"subitem_description":"身体組織からみた思春期(<特集>思春期のからだ)","subitem_description_type":"Other"},{"subitem_description":"肥満小児に対する食事療法と運動療法を主体とした減量が血中グレリン濃度に及ぼす影響","subitem_description_type":"Other"},{"subitem_description":"Quantitative insulin sensitivity check index is a useful indicator of insulin resistance in japanese metabolically obese, normal-weight subjects with normal glicose tolerance","subitem_description_type":"Other"},{"subitem_description":"Physical activity in obese students with mental retardation : An attempt to increase the number of steps at school","subitem_description_type":"Other"},{"subitem_description":"Decreased circulating levels of active ghrelin are associated with increased oxidative stress in obese subjects","subitem_description_type":"Other"},{"subitem_description":"Increased oxidative stress is associated with decreased circulating levels of adiponectin in Japanese metabolically obese, nomal-weight men with nomal glucose tolerence","subitem_description_type":"Other"},{"subitem_description":"Decreased high-molecular weight adiponectin-to-total adiponectin ratio in sera is associated with insulin resistance in japanese metabolically obese, normal-weight men with normal glucose tolerance","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17500470","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"冨樫, 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