@article{oai:mie-u.repo.nii.ac.jp:00007474,
 author = {高野, 頌 and Takano, Hiroshi and 小島, 沙耶香 and Kojima, Sayaka and 伊藤, 正行 and Itoh, Masayuki and 兵, 昇 and Hyo, Noboru and 間島, 雄一 and Majima, Yuichi},
 issue = {suppl. 1},
 journal = {耳鼻咽喉科展望},
 month = {Apr},
 note = {application/pdf, 非球状ドライパウダー吸入剤の気道内沈着における空気力学径について検討した.方法は,気流中の非球状粒子を回転楕円体として近似し,気流中での配向角及びアスペクト比を因子に空気力学径を数値解析し,針状ガラス繊維粒子の実験で空気力学径を測定した.その結果,一様な気流速度では主軸が流れに沿って平行となる配向角を示し,速度勾配がある気流ではアスペクト比が大きい非球状粒子ほど主軸が一定の配向角を取り,多くの粒子は20～30度の配向角を示した.また,実験で測定した針状ガラス線維粒子の空気力学径と,飛行時間法による空気力学径測定器で直接的に測定した針状ガラス線維粒子の空気力学径は,ほぼ同様の結果であった.更に空気力学径を基準とした上・下気道への薬剤粒子の局所沈着率は,平常時呼吸と高負荷時呼吸では明らかに沈着特性が変化し,特に上気道への沈着率が極めて低かった, Drug inhalation is regarded as the main therapy in the superior local deposition effect on the basis of drug delivery system(DDS). The local deposition fraction of　drug particles is determined from an aerodynamic diameter as functions of particle　size, shape, density, configuration, and　orientation angle. Theoretical and experimental clarifications of the aerodynamic diameter for nonspherical drug particles are required to predict the amount of particles. A rotational ellipsoid approximation for nonspherical particles is applied to numerically determine the three-dimensional value of aerodynamic diameter. To evaluate local deposition of no spherical drug particles in the human airway, the aerodynamic diameter is obtained experimentally from the equilibrium orientation angle and aspect ratio of nonspherical drug particles. The orientation angle of nonspherical particles in air fluid was calculated numerically. the two-dimension configuration, orientation, and velocity of nonspherical particles were measured in fluid by optical microscopy and a high-speed camera to obtain the aerodynamic diameter of particles. The aerodynamic diameter of particles was also measured directly by time-of-flight (TOF), and was compared with　experimental results for measuring validity by optical microscopy. At a constant flow rate, the orientation angle was mainly on 0 degree and more homogeneous and the aerodynamic diameter measured by experiments agrees approximately with the date measured by TOF. We confirmed that more particles are aligned at 10~30 degrees decline with the flow direction in the shear flow. The aerodynamic diameter affected by orientation　angle measured in the shear flow was slightly smaller　than that measured by TOF. These results indicate that the experimental method is　useful for measuring the aerodynamic diameter of particles in an　arbitrary　fluid. More effective treatment is expected from evaluating the physical quality of pharmaceuticals such as the alteration of the aerodynamic size distribution as functions of velocity gradient, density, and configuration of particles.},
 pages = {14--19},
 title = {非球状ドライパウダー吸入剤の気道内沈着における空気力学径の検討},
 volume = {47},
 year = {2004},
 yomi = {タカノ, ヒロシ and コジマ, サヤカ and イトウ, マサユキ and ヒョウ, ノボル and マジマ, ユウイチ}
}