{"created":"2023-06-19T11:39:28.102623+00:00","id":7531,"links":{},"metadata":{"_buckets":{"deposit":"6d0792ec-1860-4dc8-ade3-c94172a3ed4c"},"_deposit":{"created_by":15,"id":"7531","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7531"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007531","sets":["334:606:607"]},"author_link":["18174","18175","18176","18177"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"213","bibliographicPageStart":"207","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"環境変異原研究"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Reactive oxygen species are capable of causing damage to various cellular constituents, such as DNA, proteins and lipids, leading to carcinogenesis, aging and a number of diseases. We have investigated the sequence specificity of oxidative stress-mediated DNA damage by using ^<32>P-labeled DNA fragments obtained from the human c-Ha-ras-1, p53 and p16 genes. The sequence specificity of DNA damage plays the key role in the mutagenic process, and affects the mutation frequency. Therefore, investigation on sequence specificity of DNA damage would provide clues on the biological significance of DNA damage which in turn may be beneficial for cancer prevention strategy. Here we discuss the mechanisms and sequence specificity of DNA damage caused by various environmental chemicals and UVA-activated photosensitizers in relation to carcinogenesis and aging.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本環境変異原学会"}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本環境変異原学会","subitem_rights_resource":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN1006217X","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0910-0865","subitem_source_identifier_type":"PISSN"}]},"item_10001_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_10001_text_25":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Mechanism of oxidative DNA damage by environmental chemicals and its role in carcinogenesis and aging"}]},"item_10001_text_41":{"attribute_name":"シリーズ","attribute_value_mlt":[{"subitem_text_value":"http://ci.nii.ac.jp/naid/110001710497/"}]},"item_10001_text_70":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Journal Article / 学術雑誌論文"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"及川, 伸二","creatorNameLang":"ja"},{"creatorName":"Oikawa, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村田, 真理子","creatorNameLang":"ja"},{"creatorName":"Murata, Mariko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平工, 雄介","creatorNameLang":"ja"},{"creatorName":"Hiraku, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川西, 正祐","creatorNameLang":"ja"},{"creatorName":"Kawanishi, Shosuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30A6625.pdf","filesize":[{"value":"761.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30A6625.pdf","url":"https://mie-u.repo.nii.ac.jp/record/7531/files/30A6625.pdf"},"version_id":"3e08da2c-dc2a-45fc-9447-125ac1e89f8e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DNA damage","subitem_subject_scheme":"Other"},{"subitem_subject":"carcinogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"aging","subitem_subject_scheme":"Other"},{"subitem_subject":"environmental chemicals","subitem_subject_scheme":"Other"},{"subitem_subject":"reactive oxygen species","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"環境因子による酸化的DNA損傷とがん,老化 : 第12回公開シンポジウム : 活性酸素の分子病態学","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"環境因子による酸化的DNA損傷とがん,老化 : 第12回公開シンポジウム : 活性酸素の分子病態学","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"15","path":["607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-03-03"},"publish_date":"2008-03-03","publish_status":"0","recid":"7531","relation_version_is_last":true,"title":["環境因子による酸化的DNA損傷とがん,老化 : 第12回公開シンポジウム : 活性酸素の分子病態学"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-10-11T05:06:49.359439+00:00"}