{"created":"2023-06-19T11:39:28.314786+00:00","id":7536,"links":{},"metadata":{"_buckets":{"deposit":"2e6c3b9f-9623-4720-b128-0f6fe5fe8433"},"_deposit":{"created_by":15,"id":"7536","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7536"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007536","sets":["334:606:607"]},"author_link":["18211","18212","18213","18214","18215","18216","18217","18218","18219","18220","18221","18222","18223","18224","18225","18226"],"control_number":"7536","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-07-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1954","bibliographicPageStart":"1946","bibliographicVolumeNumber":"116","bibliographic_titles":[{"bibliographic_title":"The journal of clinical investigation"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bacterial vectors may offer many advantages over other antigen delivery systems for cancer vaccines. We engineered a Salmonella typhimurium vaccine strain to deliver the NY-ESO-1 tumor antigen (S. typhimurium-NY-ESO-1) through a type III protein secretion system. The S. typhimurium-NY-ESO-1 construct elicited NY-ESO-1-specific CD8+ and CD4+ T cells from peripheral blood lymphocytes of cancer patients in vitro. Oral administration of S. typhimurium-NY-ESO-1 to mice resulted in the regression of established NY-ESO-1-expressing tumors. Intratu-moral inoculation of S. typhimurium-NY-ESO-1 to NY-ESO-1-negative tumors resulted in delivery of antigen in vivo and led to tumor regression in the presence of preexisting NY-ESO-1-spedific CD8+ T cells. Specific T cell responses against at least 2 unrelated tumor antigens not contained in the vaccine were observed, demonstrating epitope spreading. We propose that antigen delivery through the S. typhimurium type III secretion system is a promising novel strategy for cancer vaccine development.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Clinical Investigation"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1172/JCI28045","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.jci.org/articles/view/JCI28045"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.pubmedcentral.nih.gov/articlerender.fcgi?pubmedid=16794737"}]}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00695520","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9738","subitem_source_identifier_type":"PISSN"}]},"item_10001_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_10001_text_68":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"出版者版電子ジャーナルあり"}]},"item_10001_text_70":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Journal Article / 学術雑誌論文"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishikawa, Hiroyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18211","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Eiichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Brions, Gabriel","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18213","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chen, Li-Mei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuo, Mitsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18215","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagata, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18216","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ritter, Gerd","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18217","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jäger, Elke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18218","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nomura, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18219","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Shigeto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18220","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tawara, Isao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18221","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Takuma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18222","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiku, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18223","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Old, Lloyd J.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18224","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Galán, Jorge E.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18225","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gnjatic, Sacha","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18226","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30A7841.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30A7841.pdf","url":"https://mie-u.repo.nii.ac.jp/record/7536/files/30A7841.pdf"},"version_id":"1d8eb609-78f3-47ed-839d-51176fda4bd8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccins","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccins","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-10-24"},"publish_date":"2008-10-24","publish_status":"0","recid":"7536","relation_version_is_last":true,"title":["In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccins"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-10-23T01:45:37.661626+00:00"}