@article{oai:mie-u.repo.nii.ac.jp:00007540,
 author = {Suzuki, Shinya and Takeuchi, Kazuhiko and Majima, Yuichi},
 issue = {9},
 journal = {Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
 month = {Sep},
 note = {application/pdf, BACKGROUND: Histamine is an important chemical mediator of allergic rhinitis (AR). Histamine H₃ receptors H₃ are located on cholinergic and NANC neurons of the myenteric plexus, and activation of H₃R regulates gastric acid secretion. However, little is known about the localization and function of H₃R in the upper airway. 
OBJECTIVE: The objective of this study was to examine the localization and possible function of H₃R in the nasal mucosa. 
METHODS: We extracted total RNA from the inferior turbinate mucosa of patients with allergic rhinitis. Histamine H₃ receptor mRNA and β-actin mRNA were amplified by RT-PCR. We used immunohistochemistry to examine localization of H₃ receptor protein in the inferior turbinate mucosa excised during clinically indicated surgery. We used alcian blue/periodic acid-shiff(AB/PAS) staining to examine the effects of the histamine H₃ receptor agonist (R)-α-methylhistamine and the histamine H₃ receptor antagonist thioperamide on secretion from rat submucosal glands. 
RESULTS: Histamine H₃ receptor protein was expressed around submucosal gland cells. Thioperamide induced degranulation in the submucosal gland in the nasal septum. 
CONCLUSION: The present results suggest that histamine H₃ receptor is localized mainly around submucosal glands, and that histamine H₃ receptor plays an important part in secretion of submucosal glands in the nose., 上気道のリモデリングの特異性とその制御},
 pages = {1476--1482},
 title = {Localization and function of histamine H₃ receptor in the nasal mucosa},
 volume = {38},
 year = {2008}
}