{"created":"2023-06-19T11:39:28.493564+00:00","id":7540,"links":{},"metadata":{"_buckets":{"deposit":"4c26f2e5-8a09-4d22-b852-5a0f95ccfee9"},"_deposit":{"created_by":15,"id":"7540","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7540"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007540","sets":["334:606:607"]},"author_link":["18236","18237","18238"],"control_number":"7540","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1482","bibliographicPageStart":"1476","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: Histamine is an important chemical mediator of allergic rhinitis (AR). Histamine H₃ receptors H₃ are located on cholinergic and NANC neurons of the myenteric plexus, and activation of H₃R regulates gastric acid secretion. However, little is known about the localization and function of H₃R in the upper airway. \nOBJECTIVE: The objective of this study was to examine the localization and possible function of H₃R in the nasal mucosa. \nMETHODS: We extracted total RNA from the inferior turbinate mucosa of patients with allergic rhinitis. Histamine H₃ receptor mRNA and β-actin mRNA were amplified by RT-PCR. We used immunohistochemistry to examine localization of H₃ receptor protein in the inferior turbinate mucosa excised during clinically indicated surgery. We used alcian blue/periodic acid-shiff(AB/PAS) staining to examine the effects of the histamine H₃ receptor agonist (R)-α-methylhistamine and the histamine H₃ receptor antagonist thioperamide on secretion from rat submucosal glands. \nRESULTS: Histamine H₃ receptor protein was expressed around submucosal gland cells. Thioperamide induced degranulation in the submucosal gland in the nasal septum. \nCONCLUSION: The present results suggest that histamine H₃ receptor is localized mainly around submucosal glands, and that histamine H₃ receptor plays an important part in secretion of submucosal glands in the nose.","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"上気道のリモデリングの特異性とその制御","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Scientific Publications"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18564330","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1365-2222.2008.03041.x","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10692471","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1365-2222","subitem_source_identifier_type":"PISSN"}]},"item_10001_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_10001_text_43":{"attribute_name":"著作の一部","attribute_value_mlt":[{"subitem_text_value":"http://hdl.handle.net/10076/10174"}]},"item_10001_text_70":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Journal Article / 学術雑誌論文"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Shinya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeuchi, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Majima, Yuichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"takeuchi_3.pdf","filesize":[{"value":"12.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"takeuchi_3.pdf","url":"https://mie-u.repo.nii.ac.jp/record/7540/files/takeuchi_3.pdf"},"version_id":"bb3a992c-1f02-4dae-9887-8025c5eca97e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"histamine H₃ receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"(R)-α-methylhistamine","subitem_subject_scheme":"Other"},{"subitem_subject":"thioperamide","subitem_subject_scheme":"Other"},{"subitem_subject":"submucosal gland","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Localization and function of histamine H₃ receptor in the nasal mucosa","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Localization and function of histamine H₃ receptor in the nasal mucosa","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-04-21"},"publish_date":"2009-04-21","publish_status":"0","recid":"7540","relation_version_is_last":true,"title":["Localization and function of histamine H₃ receptor in the nasal mucosa"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-10-23T01:21:54.112549+00:00"}