{"created":"2023-06-19T11:39:29.520564+00:00","id":7564,"links":{},"metadata":{"_buckets":{"deposit":"84a941a4-e76b-450a-88cd-986a2fe9001f"},"_deposit":{"created_by":15,"id":"7564","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7564"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007564","sets":["334:606:607"]},"author_link":["18363"],"control_number":"7564","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"48","bibliographicPageStart":"37","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"日本味と匂学会誌"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"交通事故などで生じる頭部外傷は、副鼻腔炎、感冒とともに嗅覚障害の三大原因のひとつであり、他の原因と比較して嗅覚の予後が悪い。本来嗅神経には他の脳神経よりも強い再生能力が備わっているにもかからわず、外傷性嗅覚障害の予後成績がよくないのはなぜか?これを突き止めるために外傷性嗅覚障害モデルマウスを用いて予後因子の探究と予後改善のための治療研究を施行した。嗅神経の確認が容易なOMP-tau-lacZマウスを用い、2種類のカッターを使い分けて嗅神経を切断して軽傷と重傷の外傷性嗅覚障害モデルを作製し、篩板-嗅球創部の傷害組織の所見、局所炎症の程度、嗅神経の再生度を比較検討した。その結果、外傷性嗅覚障害の予後は局所炎症の程度に依存し、外傷後早期に積極的な消炎治療を施行すれば、外傷性嗅覚障害の予後成績を改善できる可能性が示唆された。消炎治療薬として抗IL-6受容体抗体はステロイドよりも副作用が少なく、実際に臨床応用できる外傷性嗅覚障害の有効な治療薬の候補であると考えられる。","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"総説特集II 嗅覚系の発生・再生・加齢－2","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本味と匂学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11426393","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13404806","subitem_source_identifier_type":"PISSN"}]},"item_10001_text_25":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Research for regenerative treatment of olfactory dysfunction following head trauma by control of local inflammation"}]},"item_10001_text_70":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Journal Article / 学術雑誌論文"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 正佳","creatorNameLang":"ja"},{"creatorName":"Kobayashi, Masayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30A16902.pdf","filesize":[{"value":"573.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30A16902.pdf","url":"https://mie-u.repo.nii.ac.jp/record/7564/files/30A16902.pdf"},"version_id":"fb14218d-fd09-43bb-8faf-153663eb8949"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"外傷性嗅覚障害","subitem_subject_scheme":"Other"},{"subitem_subject":"神経再生","subitem_subject_scheme":"Other"},{"subitem_subject":"OMP-tau-lacZマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"ステロイド","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-6","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"炎症制御による外傷性嗅覚障害の再生治療研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症制御による外傷性嗅覚障害の再生治療研究","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"15","path":["607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-05-22"},"publish_date":"2014-05-22","publish_status":"0","recid":"7564","relation_version_is_last":true,"title":["炎症制御による外傷性嗅覚障害の再生治療研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-10-11T23:38:18.227954+00:00"}