@phdthesis{oai:mie-u.repo.nii.ac.jp:00007830,
 author = {KITAJIMA, TAKAHITO and 北嶋, 貴仁},
 month = {Jan},
 note = {application/pdf, Background: Vasohibin-1 (VASHI) is related to angiogenesis and poor prognosis in several types of cancers. However, the biological function and clinical significance of VASHI in colorectal cancer (CRC) are not fully known. Materials and Methods: The associations between VASHI expression and clinicopathological features were investigated by immunohistochemistry in 429 CRC tissues. To evaluate the function of VASHI in vitro, small-interfering VASHT targeting RNA was transfected into human CRC cell lines. Results: We found that VASHI was highly expressed in the cytoplasm of CRC tissues. High VASHI expression in the cytoplasm was significantly associated with tumor progression, such as larger tumor size, advanced T-stage, lymph node metastasis, distant metastasis and poor prognosis. Moreover, a significant positive correlation was detected between VASH1 expression and microvessel density. VASHI siRNA inhibited CRC cell proliferation, migration, and invasion, and promoted anoikis. Conclusion: Overexpression of VASHI in CRC cells increased malignant potential and promoted metastasis., 本文 / Department of Gastrointestinal and Pediatric Surgery，Mie University Graduate School of Medicine, 10p},
 school = {三重大学},
 title = {Vasohibin-1 Increases the Malignant Potential of Colorectal Cancer and Is a Biomarker of Poor Prognosis},
 year = {2015},
 yomi = {キタジマ, タカヒト}
}