{"created":"2023-06-19T11:39:47.279356+00:00","id":7964,"links":{},"metadata":{"_buckets":{"deposit":"d5cd663c-e335-4983-a6b0-9475aebdf21d"},"_deposit":{"created_by":15,"id":"7964","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7964"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007964","sets":["334:627:1692670175670"]},"author_link":["19317"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-31","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々はこれまでヒト末梢血単球の真皮型樹状細胞への分化の制御機構におけるサイトカインの役割についての研究を遂行してきた。本研究では、B細胞の抗原提示細胞への分化とホジキンリンパ腫の病態との関連性について研究を開始した。その過程で、ヒト末梢血単球が皮膚環境で産生されるNotchリガンド Delta-1、GM-CSF、TGF-β1の存在下でLangerhans細胞に分化することを見出した。これらの細胞はCD1a、E- Cadherin、Langerin、CCR6を発現し、Birbeck顆粒を有していた。また、貪食能とMIP-3αに対する走化性を示した。TNF- αとCD40リガンドで分化させると、MIP-3βに対する走化性を獲得し、CD4陽性T細胞とCD8陽性T細胞を刺激した。GM-CSFとIL-3はシグナル伝達に関与する受容体subunitを共有するが、IL-3は皮膚環境において構成的には産生されていない。そこで、末梢血単球の Langerhans細胞への分化におけるGM-CSFの皮膚環境での位置づけをより明確にするために、GM-CSFとIL-3を比較検討した。GM- CSFをIL-3に替えて培養すると、末梢血単球はLangerhans細胞へ分化しなかった。末梢血単球のLangerhans細胞へ分化におけるGM -CSFの不可欠性を示している。予備的実験において、遺伝子の発現プロファイルをmicroarrayで解析したところ、GM-CSF+TGF-β1+ Delta-1で生成されたLangerhans細胞とIL-3+TGF-β1+Delta-1で培養された細胞は、異なったプロファイルを示した。末梢血単球のLangerhans細胞へ分化における皮膚環境の重要性を示している。","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成17年度～平成18年度科学研究費補助金基盤研究(C)(2)研究成果報告書","subitem_description_type":"Other"},{"subitem_description":"津","subitem_description_type":"Other"}]},"item_8_description_62":{"attribute_name":"目次","attribute_value_mlt":[{"subitem_description":"IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into langerhans cells","subitem_description_type":"Other"},{"subitem_description":"Clinical and prognostic significance of cytokine recepter expression in acute lymphoblastic leukemia:interleukin-2 receptor α-chain predicts a poor prognosis","subitem_description_type":"Other"},{"subitem_description":"Detection of the CBFB/MYHII fusion gene in de novo acute myeloid leukemia(AML) : A simgle-institution study of 224 Japanese AML patients","subitem_description_type":"Other"},{"subitem_description":"Differential cell division history between neutrophils and macrophages in their development from granulocyte-macrophage progenitors","subitem_description_type":"Other"},{"subitem_description":"Pleiotropic role of histone deacetylases in the regulation of human adult erythropoiesis","subitem_description_type":"Other"},{"subitem_description":"A novel role for notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes","subitem_description_type":"Other"},{"subitem_description":"Ex vivo generation of human peripheral blood monocyte-derived antigen presenting cells","subitem_description_type":"Other"},{"subitem_description":"Hematopoietic origin of hepatic stellate cell","subitem_description_type":"Other"},{"subitem_description":"Differential requirement for cell division in the development of terminally differentiated neutrophils and macrophages from their common progenitors","subitem_description_type":"Other"},{"subitem_description":"Divergent roles of histone deacetylases in human adult eythropoiesis","subitem_description_type":"Other"},{"subitem_description":"ヒト赤芽球前駆細胞の増殖・分化・生存におけるヒストン脱アセチル化酵素の造血因子特異的な制御","subitem_description_type":"Other"},{"subitem_description":"なぜ造血回復期に単球が好中球に先行して末梢血中に出現するのか？－その機序の説明－","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17590993","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"片山直之"}]},"item_8_relation_46":{"attribute_name":"部分を持つ","attribute_value_mlt":[{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7501","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7515","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7520","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7521","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7522","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7523","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7531","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7525","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7526","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7532","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7536","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7537","subitem_relation_type_select":"URI"}}]},"item_8_subject_16":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken 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