{"created":"2023-06-19T11:39:47.450692+00:00","id":7968,"links":{},"metadata":{"_buckets":{"deposit":"c97f8bbf-1842-4f9e-9ece-8ccdd5d8409d"},"_deposit":{"created_by":15,"id":"7968","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7968"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007968","sets":["334:627:1692670175670"]},"author_link":["19322","19323","19324"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-01","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"梗塞後の心室リモデリング進展におけるテネイシンCの役割を解明するために、ノックアウトマウスを用いて心筋梗塞モデルを作成し野性型と対比した。12週令オスBalb/cバックグラウンドテネイシンCノックアウトマウス(KO:n=30)および野生型マウス(Wt:n=37)の冠動脈結紮したところ、KO12匹、WT17匹が1日以内に急性心不全で死亡、その後28日までにKO1匹,WT4匹が心不全で死亡したが生存率には差は認められないと考えられた。ノックアウトの1匹は8日後心破裂で死亡した。28日後KO, WTそれぞれ16匹について心機能を解析すると拡張末期径、左室拡張末期圧はノックアウトの方が有意に低く、テネイシンCがない方が心機能の改善が良好であった。梗塞巣の大きさには差は見られなかった。これは、急性心筋梗塞後テネイシンCが高い患者では6ヶ月後に心室リモデリングをおこす頻度が高く、慢性期の心機能回復が不良で予後が悪いという我々の最近の結果と一致した。\nさらに、CAGプロモーターとマウステネイシンC遺伝子の間にloxではさんだstopを挿入したトランスジェニックマウスを作成し、α-myosin heavy chain(αMHC)プロモーターCrePRIマウスと交配してテネイシンCの心臓での過剰発現を試みた。理論的には、このマウスではタモキシフェン投与によりαMHCを発現させ、Cre recombinationを誘導できるが,実際にはleakがあり、誘発をかけなくても,生後6週ごろから、本来なら正常で発現しない心筋細胞がテネイシンCを産生、周囲間質に分泌することが確認された。Recombinationによる過剰発現は少なくとも31週令まで持続していることが確認できたが、現在のところ、過剰発現させただけでは心臓に明らかな変化を認めていない。","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成17年度～平成18年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_62":{"attribute_name":"目次","attribute_value_mlt":[{"subitem_description":"Serum tenascn-C might be a novel predictor of left ventricular remodeling and prognosis after acute myocardial infarction","subitem_description_type":"Other"},{"subitem_description":"Higher serum Tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy","subitem_description_type":"Other"},{"subitem_description":"Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse : involvement of tenesin-C induced by aldosterone-mediated inflammation","subitem_description_type":"Other"},{"subitem_description":"Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice","subitem_description_type":"Other"},{"subitem_description":"Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse","subitem_description_type":"Other"},{"subitem_description":"Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C","subitem_description_type":"Other"},{"subitem_description":"A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy","subitem_description_type":"Other"},{"subitem_description":"In vitro model for mouse coronary vasculogenesis","subitem_description_type":"Other"},{"subitem_description":"Tenascin-C-coated platinum coils for acceleration of organization of cavities and reduction of lumen size in a rat aneurysm model","subitem_description_type":"Other"},{"subitem_description":"テネイシンC(不全心の分子機構に関する最新の基礎研究　心筋リモデリングの分子機構　心筋間質の線維化)","subitem_description_type":"Other"},{"subitem_description":"心血管リモデリングとテネイシンC(<特集>)細胞外マトリクスと心血管リモデリング","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17590724","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"吉田(今中)恭子"}]},"item_8_relation_46":{"attribute_name":"部分を持つ","attribute_value_mlt":[{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7744","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7745","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7746","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7747","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7780","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7823","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7824","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7825","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7826","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7829","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10076/7827","subitem_relation_type_select":"URI"}}]},"item_8_subject_16":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken 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