{"created":"2023-06-19T11:39:48.045595+00:00","id":7982,"links":{},"metadata":{"_buckets":{"deposit":"b4fa7b07-6062-44b3-bb8a-f20d96bf4bfd"},"_deposit":{"created_by":15,"id":"7982","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7982"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007982","sets":["334:627:1692670284109"]},"author_link":["19362","19363","19364","19365","19366","19367"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-11","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は、細胞外基質タンパクであるデコリンが、骨肉腫細胞の肺転移を協力に抑制し、乳癌の骨転移も抑制することを発見した。さらに、デコリンの抗腫瘍効果発現最小領域を検討したところ、コアタンパクのLeucine-rich repeat内のTGF-β結合部位である事を明らかにした。デコリンは生体内に細胞外基質タンパクとして大量に存在する\"\"ありふれたタンパク\"\"であるが、安全な抗腫瘍薬となる可能性があることがわかった。","subitem_description_type":"Abstract"},{"subitem_description":"We discovered that decorin suppress lung metastasis of osteosarcoma and bone metastasis of breast cancer. Furthermore, we showed that minimum active region for anti-tumor effect may be the TGF-b binding site which exists in the core protein of decorin. Decorin is a natural product and has no immunogenicity. Therefore, these results suggest that decorin represents the new therapeutic modality to prevent pulmonary metastasis in osteosarcoma.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成20~22年度科学研究費補助金（基盤研究(C)）研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20591752","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Novel therapy for metastatic sarcoma to the lung using extracellular matrix protein : decorin."}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松峯, 昭彦","creatorNameLang":"ja"}],"familyNames":[{"familyName":"MATSUMINE, Akihiko","familyNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内田, 淳正","creatorNameLang":"ja"},{"creatorName":"UCHIDA, Atsumasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠崎, 克之","creatorNameLang":"ja"},{"creatorName":"KUSUZAKI, Katsuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"若林, 弘樹","creatorNameLang":"ja"},{"creatorName":"WAKABAYASHI, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"熊本, 忠史","creatorNameLang":"ja"},{"creatorName":"KUMAMOTO, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"明田, 浩司","creatorNameLang":"ja"}],"familyNames":[{"familyName":"AKEDA, Koji","familyNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16724.pdf","filesize":[{"value":"567.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16724.pdf","url":"https://mie-u.repo.nii.ac.jp/record/7982/files/30K16724.pdf"},"version_id":"5d5c32c3-21c0-4fb5-a898-c13cc6a9f1b2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"デコリン","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外基質タンパク","subitem_subject_scheme":"Other"},{"subitem_subject":"悪性骨軟部腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"肉腫","subitem_subject_scheme":"Other"},{"subitem_subject":"遠隔転移","subitem_subject_scheme":"Other"},{"subitem_subject":"肺転移","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肉腫肺転移に対する、デコリンを用いた画期的な治療戦略の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肉腫肺転移に対する、デコリンを用いた画期的な治療戦略の確立","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670284109"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"7982","relation_version_is_last":true,"title":["肉腫肺転移に対する、デコリンを用いた画期的な治療戦略の確立"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T04:07:31.809907+00:00"}