{"created":"2023-06-19T11:39:48.087471+00:00","id":7983,"links":{},"metadata":{"_buckets":{"deposit":"33708578-b2d4-4916-8e48-6d231e7005e9"},"_deposit":{"created_by":15,"id":"7983","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7983"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007983","sets":["334:627:1692670315782"]},"author_link":["19374","19375"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-18","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"GITRL-Fc遺伝子発現腫瘍細胞株を用いた腫瘍細胞ワクチン療法、GITRL-Fc遺伝子を組み込んだアデノウイルス用いた遺伝子治療において、腫瘍局所のGITRL-Fcは抗腫瘍免疫を増強することを示した。ヒト腫瘍抗原MAGE-A4に特異的なT細胞レセプター遺伝子を、レトロウイルスベクターを用いてがん患者T細胞に体外で導入し患者に輸注する、進行期食道癌に対する遺伝子改変T細胞輸注療法臨床試験を開始した。インテグリン刺激とCD4T細胞のヘルプが、腫瘍特異的CD8陽性T細胞のマルチファンクション性獲得と生存性を向上させることを見出した。","subitem_description_type":"Abstract"},{"subitem_description":"Tumor cell vaccine expressing GITRL-Fc and gene therapy with adenovirus encoding GITRL-Fc were found to be effective in cancer immunotherapy. We started a clinical trial with TCR-gene modified T cells that express MAGE-A4-specific TCR for patients with advanced esophageal cancer. Stimulation through integrin molecules and CD4 T cell-help were found to enhance multifunctionality and survival of tumor specific CD8+ T cells.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成21~23年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21591664","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Development of a novel cellular vaccine of GITRL-Fc expressing tumor cells for treatment of patients with advanced malignancy"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 裕明","creatorNameLang":"ja"},{"creatorName":"IKEDA, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西川, 博嘉","creatorNameLang":"ja"},{"creatorName":"NISHIKAWA, Hiroyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16827.pdf","filesize":[{"value":"334.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16827.pdf","url":"https://mie-u.repo.nii.ac.jp/record/7983/files/30K16827.pdf"},"version_id":"6ade3f07-5cac-4832-a4e2-0c9ead5088fe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GITRL","subitem_subject_scheme":"Other"},{"subitem_subject":"GITRL-Fc","subitem_subject_scheme":"Other"},{"subitem_subject":"抗腫瘍免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞マルチファンクション性","subitem_subject_scheme":"Other"},{"subitem_subject":"制御性T細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞移入療法","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子療法","subitem_subject_scheme":"Other"},{"subitem_subject":"siTCRベクター","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"難治性癌に対するＧＩＴＲＬーＦｃ融合蛋白発現腫瘍による新規腫瘍細胞ワクチンの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"難治性癌に対するＧＩＴＲＬーＦｃ融合蛋白発現腫瘍による新規腫瘍細胞ワクチンの開発","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670315782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"7983","relation_version_is_last":true,"title":["難治性癌に対するＧＩＴＲＬーＦｃ融合蛋白発現腫瘍による新規腫瘍細胞ワクチンの開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T04:41:01.129834+00:00"}