{"created":"2023-06-19T11:39:48.255030+00:00","id":7987,"links":{},"metadata":{"_buckets":{"deposit":"eca4528d-7a60-4567-9ce2-8534eabf2109"},"_deposit":{"created_by":15,"id":"7987","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7987"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007987","sets":["334:627:1692670245812"]},"author_link":["19386"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-13","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"炎症性サイトカインのTNFalphaとTGFbeta1を加えることにより、MUC2遺伝子発現の亢進はみられた。しかしMUC5AC遺伝子発現については、TGFbeta1はTNFalpha刺激で誘導されるMUC5AC遺伝子発現を抑制していた。これは当初の予想と異なり、TGFbeta1はムチンの種類によってはリモデリングを抑制する方向に働く可能性を示唆していると思われた。また今回の結果からはMUC2とMUC5AC遺伝子発現に関しTGFbeta1は異なった細胞内シグナル伝導経路を用いていることも判明した。","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成19~20年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19791205","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"The role of TGFbeta1 on remodeling for chronic upper airway epithelium"}]},"item_8_text_65":{"attribute_name":"資源タイプ(三重大)","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石永, 一","creatorNameLang":"ja"},{"creatorName":"ISHINAGA, Hajime","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16632.pdf","filesize":[{"value":"244.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16632.pdf","url":"https://mie-u.repo.nii.ac.jp/record/7987/files/30K16632.pdf"},"version_id":"535e1d55-bd25-4f80-b03b-c4406638871b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ムチン遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"TGFβ","subitem_subject_scheme":"Other"},{"subitem_subject":"リモデリング","subitem_subject_scheme":"Other"},{"subitem_subject":"粘液分泌","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"上気道慢性炎症でのリモデリングにおけるTGFβ1の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"上気道慢性炎症でのリモデリングにおけるTGFβ1の役割","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670245812"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"7987","relation_version_is_last":true,"title":["上気道慢性炎症でのリモデリングにおけるTGFβ1の役割"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T02:39:21.942241+00:00"}