{"created":"2023-06-19T11:39:48.297173+00:00","id":7988,"links":{},"metadata":{"_buckets":{"deposit":"0cfd9f3c-c38d-48b3-90f8-326493fa8c4d"},"_deposit":{"created_by":15,"id":"7988","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7988"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007988","sets":["334:627:1692670315782"]},"author_link":["19388","19389"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06-10","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ラット過少グラフト移植モデルにおいて,保存液に活性型プロテインCを添加すると肝細胞保護作用があり移植後の肝虚血再潅流障害を軽減することが明らかにされた.さらに脾摘は過小グラフト肝の肝障害を軽減させ,その機序として脾臓からの炎症細胞のmigrationの抑制が示唆された.臨床的には過小グラフトを克服するには門脈圧のコントロールが重要で,術前に脾臓容積とグラフト重量を計測することで脾摘の効果が予測できることが判明した.","subitem_description_type":"Abstract"},{"subitem_description":"Small-for-size liver grafts are a serious obstacle for partial orthotopic liver transplantation. The results using a rat model suggest that a preservation solution containing APC is a potential novel and safe product for small-for-size liver transplantation, alleviating graft injury via anti-inflammatory and antiapoptotic effects and vasorelaxing conditions. Additionally, splenectomy before transplantation inhibited leukocyte infiltrations and pro-inflammatory cytokine synthesis which leads to hepatocellular apoptosis and impaired liver regeneration. Clinically, control of portal venous pressure immediately after living donor liver transplantation using small-for-size liver graft is very important, and preoperative assessment of the recipient's spleen volume and graft volume is very helpful to determine the necessity of splenectomy.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成21~23年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21591747","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"CHALLNEGE TO OVERCOME LIVING DONOR LIVER TRANSPLANTATION USING SMALL-FOR-SIZE GRAFT"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊佐地, 秀司","creatorNameLang":"ja"},{"creatorName":"ISAJI, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田端, 正己","creatorNameLang":"ja"},{"creatorName":"TABATA, Masami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19389","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16829.pdf","filesize":[{"value":"325.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16829.pdf","url":"https://mie-u.repo.nii.ac.jp/record/7988/files/30K16829.pdf"},"version_id":"6091a183-8ebb-48e7-94cb-b445e34c624d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"生体肝移植","subitem_subject_scheme":"Other"},{"subitem_subject":"過小グラフト","subitem_subject_scheme":"Other"},{"subitem_subject":"脾臓","subitem_subject_scheme":"Other"},{"subitem_subject":"脾摘","subitem_subject_scheme":"Other"},{"subitem_subject":"肝再生","subitem_subject_scheme":"Other"},{"subitem_subject":"肝類洞内皮","subitem_subject_scheme":"Other"},{"subitem_subject":"門脈圧","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性サイトカイン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"過少グラフトを用いた生体部分肝移植への挑戦と克服","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"過少グラフトを用いた生体部分肝移植への挑戦と克服","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670315782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"7988","relation_version_is_last":true,"title":["過少グラフトを用いた生体部分肝移植への挑戦と克服"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T04:41:05.900304+00:00"}