{"created":"2023-06-19T11:39:48.550170+00:00","id":7994,"links":{},"metadata":{"_buckets":{"deposit":"46c59e9c-6564-40d4-8191-18d3be6a0bec"},"_deposit":{"created_by":15,"id":"7994","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7994"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00007994","sets":["334:627:1692670315782"]},"author_link":["19408","19409"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-18","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アトピー性皮膚炎(AD)の免疫異常を調整する物質を検索し、治療の基礎的研究を行った。免疫調整物質を皮膚から供給するため変異型サイトカインを皮膚特異的に発現するマウスを作成した。同マウスでは実験的接触皮膚炎における皮膚腫脹が軽減され、同マウスの皮膚を移植した野生型マウスにおいても、同皮膚炎の早期の炎症が軽減し、皮膚の細胞内伝達物質のmRNA発現も減少した。表皮細胞を免疫調整物質産生臓器とする治療法は、ヒト疾患の治療への応用も考慮される基礎技術として期待される。","subitem_description_type":"Abstract"},{"subitem_description":"Immunological balance in AD is shifted to Th2 dominant conditions, and we have been investigated various therapeutic method to correct Th2 shifted immune systems based on the skin immunomodulation systems. In addition to supplementation of exogenous immunomodulators to the skin, we have developed a skin specific dominant negative type mutant IL-4 expressing transgenic mouse. This mouse decreased inflammation in a hapteninduced experimental dermatitis at the early phase. Wild type mouse with skin graft from the transgenic mouse, also decreased inflammation and Th2 cytokine signal proteins mRNA expression in the skin lesions. This concept, production of therapeutic peptide from keratinocytes, is a potent therapeutic strategy for various systemic diseases including allergic diseases.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成21~23年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21591461","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Control of allergy with skin based immunomodulation"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水谷, 仁","creatorNameLang":"ja"},{"creatorName":"MIZUTANI, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山中, 恵一","creatorNameLang":"ja"},{"creatorName":"YAMANAKA, Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19409","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16823.pdf","filesize":[{"value":"297.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16823.pdf","url":"https://mie-u.repo.nii.ac.jp/record/7994/files/30K16823.pdf"},"version_id":"8adbf03e-c4ac-47d2-8d4e-f8920cac8f42"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アトピー性皮膚炎","subitem_subject_scheme":"Other"},{"subitem_subject":"Th2","subitem_subject_scheme":"Other"},{"subitem_subject":"ワクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"表皮を免疫調整臓器とする新規アレルギー疾患治療の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"表皮を免疫調整臓器とする新規アレルギー疾患治療の開発","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670315782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"7994","relation_version_is_last":true,"title":["表皮を免疫調整臓器とする新規アレルギー疾患治療の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T04:41:11.106721+00:00"}