{"created":"2023-06-19T11:39:48.890683+00:00","id":8002,"links":{},"metadata":{"_buckets":{"deposit":"fa33a491-aeb1-45a7-8ec2-688fb929a5c6"},"_deposit":{"created_by":15,"id":"8002","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8002"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008002","sets":["334:627:1692670284109"]},"author_link":["19436"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-28","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"慢性骨髄性白血病の病態解明に有用であるヒト造血幹細胞の骨髄系細胞だけでなくB細胞とT細胞の産生能を同時に解析できる培養方法を樹立できた。BCR-ABL1をヒトCD34^+細胞に導入すると、その増殖能は亢進したが、分化能は臨床病態を反映していなかった。末梢血単球が造血幹細胞由来の肝星細胞の前駆細胞であった。急性型成人T細胞白血病/リンパ腫ではリンパ節で腫瘍細胞が発生進展し、末梢血中に出現していることが示された。","subitem_description_type":"Abstract"},{"subitem_description":"We devised a unique culture system in which the developments of B cells and T cells as well as myeloid cells from human hematopoietic stem cells can be simultaneously evaluated. BCR-ABL1-transfected human CD34^+ cells showed the highly proliferative potential with different differentiation capacity from that of chronic myelogenous leukemia-derived cells. Monocytes in the peripheral blood proved to be immediate precursors of hepatic stellate cells of hematopoietic stem cell origin. It turned out that in acute type adult T cell leukemia/lymphoma, multiple subclones of common clone origin are present in the lymph nodes and a selected subclone exits into the peripheral blood.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成21~23年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21591200","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Analysis of a role for BCR-ABL1 in the leukemogenesis using the experimental system that reflects the characteristics of human leukemia"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"片山, 直之","creatorNameLang":"ja"}],"familyNames":[{"familyName":"KATAYAMA, Naoyuki","familyNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16819.pdf","filesize":[{"value":"371.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16819.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8002/files/30K16819.pdf"},"version_id":"d09b9820-8723-4b9c-a072-f05f594bd151"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血液腫瘍学","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性骨髄性白血病","subitem_subject_scheme":"Other"},{"subitem_subject":"造血幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"BCR-ABL1遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ球分化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト疾患に近いシステムを用いた白血病発症におけるＢＣＲ―ＡＢＬ１遺伝子の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト疾患に近いシステムを用いた白血病発症におけるＢＣＲ―ＡＢＬ１遺伝子の機能解析","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670284109"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"8002","relation_version_is_last":true,"title":["ヒト疾患に近いシステムを用いた白血病発症におけるＢＣＲ―ＡＢＬ１遺伝子の機能解析"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T04:07:40.891805+00:00"}