{"created":"2023-06-19T11:39:49.062054+00:00","id":8006,"links":{},"metadata":{"_buckets":{"deposit":"f85275c0-4e23-426c-8526-294d47edc295"},"_deposit":{"created_by":15,"id":"8006","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8006"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008006","sets":["334:627:1692670315782"]},"author_link":["19448"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は今まで、ポリオウイルス（PV）の神経細胞に対する親和性に着目し、PVを神経芽腫の治療に応用しようと試みてきました。我々は、マウスを用いた研究でPVは神経芽腫細胞に対して強い抗腫瘍活性を持ち、マウスに移植した腫瘍が消失する事を報告してきました。さらに驚いたことに神経芽腫をPVで治療することで抗腫瘍免疫が誘導されることが示唆されました。以上の結果をふまえ、三重大学医学部附属病院では2010年から、再発神経芽腫の患者さんに弱毒PVの腫瘍内投与により治療する、第１相の臨床試験を開始しました。 ","subitem_description_type":"Abstract"},{"subitem_description":"In a previous study, we demonstrated that neuroblastoma subcutaneously implanted in immuno-competent mice is eliminated by intratumoral administration of neuroattenuated poliovirus (PV). Our results also suggested that the in vivo destruction of neuroblastoma cells by virotherapy lead to a robust antitumor immune response. In accordance with these findings, we started phase 1 clinical trial, novel treatment of neuroblastoma by live-attenuated poliovirus.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成21~23年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21591359","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Novel treatment of neuroblastoma by live-attenuated poliovirus"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"豊田, 秀実","creatorNameLang":"ja"},{"creatorName":"Toyoda, hidemi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16821.pdf","filesize":[{"value":"439.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16821.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8006/files/30K16821.pdf"},"version_id":"a6b7cb28-57a2-47d6-ba5e-221ac708f962"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経芽腫","subitem_subject_scheme":"Other"},{"subitem_subject":"ポリオウイルス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ポリオウイルスを用いた神経芽腫の新しい治療法の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ポリオウイルスを用いた神経芽腫の新しい治療法の研究","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670315782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"8006","relation_version_is_last":true,"title":["ポリオウイルスを用いた神経芽腫の新しい治療法の研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T04:41:30.156895+00:00"}