{"created":"2023-06-19T11:39:49.190739+00:00","id":8009,"links":{},"metadata":{"_buckets":{"deposit":"a627d20d-8fde-4d86-8cf8-77cc892ed640"},"_deposit":{"created_by":15,"id":"8009","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8009"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008009","sets":["334:627:1692670245812"]},"author_link":["19474"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-26","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"繊維・粒子状物質による発がんなどの呼吸器疾患には、慢性炎症が重要な役割を果たすと考えられる。8-ニトログアニンとは、炎症条件下で生成される変異誘発性DNA損傷塩基である。我々はアスベストを気管内投与したマウスの気道上皮で8-ニトログアニンが生成され、アスベストの発がん性の強さを反映するという注目すべき知見を得た。また感染・炎症関連発がん患者の臨床検体を用いた研究から、8-ニトログアニン生成は慢性炎症からがんの発生・進展に至る過程を反映し、発がんリスクを評価するバイオマーカーとして応用可能であることを明らかにした。","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成19~20年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19590585","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Risk assessment of pulmonary diseases caused by fibers and particlesusing nitrative DNA lesion as a potential biomarker"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平工, 雄介","creatorNameLang":"ja"},{"creatorName":"HIRAKU, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19474","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16606.pdf","filesize":[{"value":"924.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16606.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8009/files/30K16606.pdf"},"version_id":"100b356d-f3da-4f56-b2fb-7b72de33c81a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"繊維・粒子状物質","subitem_subject_scheme":"Other"},{"subitem_subject":"アスベスト","subitem_subject_scheme":"Other"},{"subitem_subject":"リスク評価","subitem_subject_scheme":"Other"},{"subitem_subject":"発がん","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"活性酸素・窒素種","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA 損傷","subitem_subject_scheme":"Other"},{"subitem_subject":"8-ニトログアニン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"繊維・粒子状物質による呼吸器疾患のニトロ化ＤＮＡ損傷を指標としたリスク評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"繊維・粒子状物質による呼吸器疾患のニトロ化ＤＮＡ損傷を指標としたリスク評価","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670245812"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"8009","relation_version_is_last":true,"title":["繊維・粒子状物質による呼吸器疾患のニトロ化ＤＮＡ損傷を指標としたリスク評価"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T02:39:31.669258+00:00"}