{"created":"2023-06-19T11:39:49.403639+00:00","id":8014,"links":{},"metadata":{"_buckets":{"deposit":"f7d51cde-9fc1-4858-abd6-b4a8ca2dbbe7"},"_deposit":{"created_by":15,"id":"8014","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8014"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008014","sets":["334:627:1692670315782"]},"author_link":["19494","19495","19496"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"テネイシン-C(TNC)は乳癌をはじめとする固形腫瘍の浸潤部位で高発現し、特に小型の癌巣を形成する乳癌浸潤部には高頻度にTNCが発現していた。乳癌細胞株MCF7をTNCで処理すると、上皮間葉移行様変化が誘導され、更にTGF-β1を加えるとそれが増強されることを見出した。この変化に関与するインテグリン(ITG)の探索を行い、ITGαvβ6とαvβ1が関与することを明らかにできた。また、ITGと複合体を形成するFAK/SRCのシグナル伝達系の活性化が関与していた。さらに、免疫組織化学によりこれらのレセプターのヒト乳癌組織での発現が確認できた。","subitem_description_type":"Abstract"},{"subitem_description":"High expression of tenascin-C(TNC) has been demonstrated in invasive fronts of various cancers including breast cancer. We found the more extensive expression in invading areas of the small cancer nests. TNC treatment in vitro induced epithelia mesenchymal transition(EMT)-like change of breast cancer cells MCF7, that was enhanced by additional transforming growth factor-beta1. We also showed the contribution of alphαvbeta6 and alphαvbeta1 integrins to this phenotypic change. Activation of FAK and SRC forming integrin adhesion complex was associated with EMT change. Immunohistochemistry of the integrins showed their expression in human breast cancer tissues.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成21~23年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21590368","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Incomplete epithelial-mesenchymal transition of breast cancer cells during cancer progression and its regulatory mechanism"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 利通","creatorNameLang":"ja"},{"creatorName":"YOSHIDA, Toshimichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, (花村)  典子","creatorNameLang":"ja"},{"creatorName":"HANAMURA, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"下條, 尚志","creatorNameLang":"ja"},{"creatorName":"SHIMOJO, Naoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16814.pdf","filesize":[{"value":"646.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16814.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8014/files/30K16814.pdf"},"version_id":"43a1d8e2-6f99-4496-82a1-ac0bf4f4cf1a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"テネイシン-C","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮間葉移行","subitem_subject_scheme":"Other"},{"subitem_subject":"乳癌","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"乳癌の進展における不完全な上皮 : 間葉移行現象とその分子機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"乳癌の進展における不完全な上皮 : 間葉移行現象とその分子機構","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670315782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"8014","relation_version_is_last":true,"title":["乳癌の進展における不完全な上皮 : 間葉移行現象とその分子機構"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T04:41:39.535753+00:00"}