{"created":"2023-06-19T11:39:49.488008+00:00","id":8016,"links":{},"metadata":{"_buckets":{"deposit":"e85631f5-d50b-4a46-b236-f57b367f70de"},"_deposit":{"created_by":15,"id":"8016","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8016"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008016","sets":["334:627:1692670264243"]},"author_link":["19504","19505"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(1) 腫瘍特異的T細胞の生体内動態と機能解析:GITR刺激による抗腫瘍効果増強及びその機序と、抗腫瘍免疫におけるCD8+T細胞のマルチファンクション性の重要性を見出した。(2) 動物モデルにおける多価性がんワクチン有効性検証:GITR刺激によるがんワクチン増強を確認し、TCR遺伝子導入T細胞を開発しその輸注療法の有効性を確認した。(3) 臨床応用可能な抗原ペプチド群同定:MAGE-A4, NY-ESO-1, SAGE由来のCD8^+及びCD4^+T細胞エピトープ群を同定した。","subitem_description_type":"Abstract"},{"subitem_description":"1) Analyses on in vivo kinetics and functions of tumor specific T cells : We found the mechanism of antitumor effect of GITR stimulation and the importance of T cell multifunctionality in antitumor immune response. 2) The verification of polyvalent cancer vaccine in animal models : We verified the enhanced antitumor effect of cancer vaccine by GITR stimulation. We developed TCR gene-modified T cells and verified the effectiveness of adoptive T cell therapy using TCR gene-modified T cells. 3) Identification of antigen peptides for clinical use: We identified the MAGE-A4-, NY-ESO-1-, and SAGE-derived antigen peptides recognized by CD8^+ and CD4^+ T cells.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成17~21年度科学研究費補助金（特定領域研究）研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17016031","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Polyvalent cancer vaccine"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"珠玖, 洋","creatorNameLang":"ja"},{"creatorName":"SHIKU, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"影山, 愼一","creatorNameLang":"ja"},{"creatorName":"KAGEYAMA, Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K16669.pdf","filesize":[{"value":"259.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K16669.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8016/files/30K16669.pdf"},"version_id":"99a82387-b2ba-4c39-bd6f-348baa1b0dd4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"癌","subitem_subject_scheme":"Other"},{"subitem_subject":"精巣抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"キラーT細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ヘルパーT細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"マルチファンクション性T細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ペプチド抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"GITR","subitem_subject_scheme":"Other"},{"subitem_subject":"TCR遺伝子改変T細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"多価性がんワクチン","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"多価性がんワクチン","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670264243"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"8016","relation_version_is_last":true,"title":["多価性がんワクチン"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T02:53:00.917285+00:00"}