{"created":"2023-06-19T11:39:50.117195+00:00","id":8031,"links":{},"metadata":{"_buckets":{"deposit":"76291bce-daef-4121-b155-74325acec8e5"},"_deposit":{"created_by":15,"id":"8031","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8031"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008031","sets":["334:627:1692670337748"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、２光子レーザー顕微鏡を用いて、NECモデルの観察し、その病態を解明することを目的とした。NECモデルの前段階として、LPS静注による敗血症モデルを作成し、腸管微小循環の変化を捉えることに成功した。腸管壁内のCapillary vesselとPost capillary venuleにおいて、LPS投与直後の敗血症急性期では，Leukocytes adhesion/ Platelets aggregation on leukocytesが経時的に増加していた。また、Blood flow velocityとShear rateは、時間経過に伴い減少する傾向がみられた．現在、ラット新生児モデルを用いたNECモデルの作成に移行中である。","subitem_description_type":"Abstract"},{"subitem_description":"This research project is making the necrotizing enterocolitis model created in beta-actin-green fluorescent protein transgenic mice observed by two-photon laser-scanning microscopy(TPLSM) , and figuring out the pathogenesis and treatment of this disease using this model and system. As for the preliminary study, we performed the LPS induced septic model mouse, and achieved the observation of dynamic pathology of intestinal microcirculation in this septic model mouse. Nest stage, we tried to performed the necrotizing enterocolitis (NEC) model in neonatal mouse induced by LPS with hypoxia (with or without hypothermia exposure).","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2011度～2012年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"23792027","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Breakthrough of the pathogenesis and treatment strategy in necrotizing enterocolitis using two-photon laser scanning microscopy based on the alarmin concept."}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小池, 勇樹","creatorNameLang":"ja"},{"creatorName":"KOIKE, YUHKI","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17230.pdf","filesize":[{"value":"423.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17230.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8031/files/30K17230.pdf"},"version_id":"708d1c8b-1348-42fd-bb93-a45285b09f8a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"先天性消化器疾患学","subitem_subject_scheme":"Other"},{"subitem_subject":"two-photon laser-scanning microscopy (TPLSM)","subitem_subject_scheme":"Other"},{"subitem_subject":"necrotizing enterocolitis (NEC) model","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アラーミン概念に基づく２光子レーザー顕微鏡を用いた壊死性腸炎の病態解明と治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アラーミン概念に基づく２光子レーザー顕微鏡を用いた壊死性腸炎の病態解明と治療戦略","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670337748"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"8031","relation_version_is_last":true,"title":["アラーミン概念に基づく２光子レーザー顕微鏡を用いた壊死性腸炎の病態解明と治療戦略"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T06:03:07.189252+00:00"}