{"created":"2023-06-19T11:39:50.375567+00:00","id":8037,"links":{},"metadata":{"_buckets":{"deposit":"9876da06-74e4-4c6b-a650-a1a38bbbb74f"},"_deposit":{"created_by":15,"id":"8037","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8037"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008037","sets":["334:627:1692670315782"]},"author_link":["19614","19615","19616"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-31","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"スギ花粉症の次世代治療に期待される舌下免疫療法を本邦で初めて小児例で検討し、安全性と有効性を確認した。同法は小児でも安全に施行でき、成人よりも効果的であった。本研究の遂行で様々な課題もわかり、特に本法が有効であったスギ花粉症例で、合併するヒノキ花粉症に無効な例が半数近く存在した。 治療と同時に作用機序解明に免疫学的変化の検討も行った。治療により、誘導性制御性T細胞の増加、治療有効群でスギ花粉特異的IgG4の増加、治療無効群で血清IL-33の増加が確認できた。血清L-31, IL17Aには変化がなかった。","subitem_description_type":"Abstract"},{"subitem_description":"We began sublingual immunotherapy (SLIT) for pediatric cedar pollinosis as a first clinical trial in Japan. SLIT is effective and safe even in Children, and its efficacy in children is better than that in adults. We found some problems from this study. Especially , we found that SLIT in about a half of for cypress pollinosis patients is not effective, even if it is effective for cedar pollinosis. We also studied immunological changes by SLIT. The results were increased inducible regulatory T cells, increased cedar pollen-specific IgG4 in the responder group for SLIT, increased serum IL-33 in the non-responder group for SLIT, and no changes of serum IL-31 or IL17A.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2010年度～2012年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"22591897","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Sublingual immunotherapy for pediatric cedar pollinosis and its mechanism by inducible regulatory T cells and IgG4."}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"湯田, 厚司","creatorNameLang":"ja"},{"creatorName":"YUTA, ATSUSHI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石永, 一","creatorNameLang":"ja"},{"creatorName":"ISHINAGA, HAJIME","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山中, 恵一","creatorNameLang":"ja"},{"creatorName":"YAMANAKA, KEI ICHI","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17176.pdf","filesize":[{"value":"329.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17176.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8037/files/30K17176.pdf"},"version_id":"70a2e8ca-0d21-4a70-a149-bdaa05e71d81"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"鼻科学","subitem_subject_scheme":"Other"},{"subitem_subject":"舌下免疫療法","subitem_subject_scheme":"Other"},{"subitem_subject":"スギ花粉症","subitem_subject_scheme":"Other"},{"subitem_subject":"制御性T細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"IgG4","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"小児スギ花粉症の舌下免疫療法と誘導性制御性Ｔ細胞およびＩｇＧ４による作用機序解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小児スギ花粉症の舌下免疫療法と誘導性制御性Ｔ細胞およびＩｇＧ４による作用機序解明","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670315782"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"8037","relation_version_is_last":true,"title":["小児スギ花粉症の舌下免疫療法と誘導性制御性Ｔ細胞およびＩｇＧ４による作用機序解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T04:41:56.202299+00:00"}