{"created":"2023-06-19T11:39:50.626133+00:00","id":8043,"links":{},"metadata":{"_buckets":{"deposit":"9c10beeb-a9b3-4f2c-b99d-1830ce895d1e"},"_deposit":{"created_by":15,"id":"8043","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8043"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008043","sets":["334:627:1692670337748"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-28","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"熱暴露およびオレイン酸静注によって生じた急性肺傷害において、肺組織で炎症関連サイトカインIl-1β、IL-6、TNF-α、MIP2、IL-10は短時間で誘導された。また、IL-1βは熱暴露後のオレイン酸静注で相乗的に増加した。すなわち、肺脂肪塞栓による急性肺傷害は先行する病態の程度によってその程度が変化する可能性が示唆された。一方、急性肺傷害に関与しているvegfa、tgfb1、gm-csfの各mRNAは短時間で上昇し、蛋白レベルでTGF-β1の上昇が認められた。これらの蛋白は短時間で死亡した事例における全身状態の指標として利用できる可能性がある。","subitem_description_type":"Abstract"},{"subitem_description":"In acute lung injury (ALI) induced by heat exposure and/or venous injection of oleic acid, Il-1β, IL-6, TNF-α, MIP2 and IL-10, which are related to inflammatory reaction, were increased at short times. In addition, IL-1β expressions of mRNA and protein were synergistically increased by venous injection of oleic acid after heat exposure, which suggested that prognosis of ALI induced by pulmonary fat embolization would be deteriorated by the severity of precedent injuries and/or diseases which can induce to pulmonary fat embolization. Moreover, mRNA expressions of vegfa, tgfb1 and gm-csf were also induced at short times after the insults, and TGF-β1 was significantly expressed as well as mRNA. These proteins would be available for evaluating general condition in forensic autopsy cases where the individual suddenly dies.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2010年度～2012年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"22790595","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Histopathological evaluation of ante-mortem general condition using immunohistochemically-stained lung"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 裕匡","creatorNameLang":"ja"},{"creatorName":"INOUE, HIROMASA","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17194.pdf","filesize":[{"value":"369.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17194.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8043/files/30K17194.pdf"},"version_id":"e57b81c4-6907-4b4b-9cec-047ae17d9892"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"法医病理学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肺免疫染色を用いた死亡前における全身状態の病理組織学的評価法に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺免疫染色を用いた死亡前における全身状態の病理組織学的評価法に関する研究","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670337748"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"8043","relation_version_is_last":true,"title":["肺免疫染色を用いた死亡前における全身状態の病理組織学的評価法に関する研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T06:03:31.237147+00:00"}