{"created":"2023-06-19T11:39:50.797882+00:00","id":8047,"links":{},"metadata":{"_buckets":{"deposit":"43f52771-a3e6-47b5-a344-978f50096386"},"_deposit":{"created_by":15,"id":"8047","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8047"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008047","sets":["334:627:1692670337748"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-11","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"くも膜下出血（SAH）後の脳損傷は重大な予後不良因子であり、その本態の１つは血液脳関門（BBB）障害である。我々はラットのSAHモデルを用いて、マトリックス細胞蛋白（MCP）の１つであるオステオポンチンがSAH後のBBB障害の回復期に誘導され、脳損傷に対し保護的に作用することを証明した。更に、別のMCP蛋白であるテネイシンCがSAH後急性期に誘導され、オステオポンチンとは逆に脳損傷を引き起こす可能性を示した。","subitem_description_type":"Abstract"},{"subitem_description":"Subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) potentially contributes to poor outcome, one of whose key pathologic manifestation is the breakdown of the blood-brain barrier (BBB). We determined the role of osteopontin (OPN), a pleiotropic extracellular matrix glycoprotein (matricellular protein [MCP]), in the post-SAH BBB disruption in rats. The OPN levels in the brain were significantly induced and peaked at 72 hours after SAH, in the recovery phase of EBI. OPN siRNA significantly blocked the endogenous OPN induction and aggravated neurological impairment and BBB disruption at 72 hours after SAH. Pre-SAH administration of recombinant OPN (r-OPN) significantly prevented a loss in body weight, neurological impairment, brain edema and BBB disruption compared with the control rats. Treatment with r-OPN was associated with the deactivation of NF-κB activity, inhibition of MMP-9 induction, and the consequent preservation of cerebral microvessel basal lamina proteins and tight junction proteins. These findings suggest the protective effects of OPN against BBB disruption after SAH. In addition, we obtained new findings, suggesting that tenascin-C, another MCP, causes brain injury after SAH.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2010年度～2012年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"22591584","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Elucidation of pathogenesis and new treatment for brain injury after subarachnoid hemorrhage"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 秀謙","creatorNameLang":"ja"},{"creatorName":"SUZUKI, HIDENORI","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17170.pdf","filesize":[{"value":"327.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17170.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8047/files/30K17170.pdf"},"version_id":"b22fdacf-8f3f-4b42-9d00-076dc1acbbf1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脳血管障害学","subitem_subject_scheme":"Other"},{"subitem_subject":"くも膜下出血","subitem_subject_scheme":"Other"},{"subitem_subject":"脳損傷","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外基質蛋白","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"くも膜下出血後脳損傷の病態解明と新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"くも膜下出血後脳損傷の病態解明と新規治療法の開発","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670337748"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"8047","relation_version_is_last":true,"title":["くも膜下出血後脳損傷の病態解明と新規治療法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T06:03:39.837586+00:00"}