{"created":"2023-06-19T11:39:50.924065+00:00","id":8050,"links":{},"metadata":{"_buckets":{"deposit":"b3d6b736-61c6-4b04-81bb-c9b801b5d85d"},"_deposit":{"created_by":15,"id":"8050","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8050"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008050","sets":["334:627:1692670337748"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"転移性骨腫瘍に対して複合治療の臨床応用の可能性を検討した。まず、炎症性サイトカインや細胞接着因子を著しく抑制するNF-kappaB decoyによる骨転移の浸潤能、増殖抑制を乳癌細胞株を用いてin vitro, in vivoで確認できた。次に、nano-particleを用いた磁性体交流磁場温熱療法による転移病巣の制御に可能性についてin vivo で確認できた。さらに、アクリジンオレンジ光線力学療法は癌の骨転移にも有用であることを細胞株で確認し、実際の臨床応用によりminimum invasive surgeryを確立した。温度感受性リポゾームを用いたラジオ波焼却術(radiofrequency ablation: RFA)により、脊椎転移のRFAがより安全に行えることを確認した。","subitem_description_type":"Abstract"},{"subitem_description":"We developed the novel physicochemical and molecular biological therapy for the metastatic bone tumors. First, we showed that NF-kappaB decoy suppress the cell invasion and cell growth of breast cancer cell line at the bone metastatic site, by inhibiting the expression of VCM-1and ICAM-1. Second, we demonstrated the effect of hyperthermic treatment strategy with magnetic nano-particle. Third, Photodynamic therapy(PDT) using acridine orange is proved to be effective treatment not only for the sarcoma, but also for metastatic bone tumors. Actually we started clinical application of PDT for the bone metastases. Finally, we developed the radiofrequency ablation (RFA) combined with thermo-sensitive liposome-embedding doxorubicin in an effort to safe and effective RFA treatment for the metastatic spinal tumor. Further investigation is necessary.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2010年度～2012年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"22591654","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Development of novel physicochemical and molecular biological therapy for the metastatic bone tumors"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加藤, 公","creatorNameLang":"ja"},{"creatorName":"KATO, KO","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松峯, 昭彦","creatorNameLang":"ja"},{"creatorName":"MATSUMINE, AKIHIKO","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中村, 知樹","creatorNameLang":"ja"},{"creatorName":"NAKAMURA, TOMOKI","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"里中, 東彦","creatorNameLang":"ja"},{"creatorName":"SATONAKA, HARUHIKO","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"内田, 淳正","creatorNameLang":"ja"},{"creatorName":"UCHIDA, ATSUMASA","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17172.pdf","filesize":[{"value":"331.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17172.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8050/files/30K17172.pdf"},"version_id":"6431c4e0-ca65-4872-9ae7-527c321ba628"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨転移","subitem_subject_scheme":"Other"},{"subitem_subject":"磁性体温熱療法","subitem_subject_scheme":"Other"},{"subitem_subject":"アクリジンオレンジ","subitem_subject_scheme":"Other"},{"subitem_subject":"ラジオ波焼灼術","subitem_subject_scheme":"Other"},{"subitem_subject":"NFκB decoy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がんの骨転移に対する物理化学的および分子生物学的治療の開発に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がんの骨転移に対する物理化学的および分子生物学的治療の開発に関する研究","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670337748"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"8050","relation_version_is_last":true,"title":["がんの骨転移に対する物理化学的および分子生物学的治療の開発に関する研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-06T06:03:48.772806+00:00"}