{"created":"2023-06-19T11:39:51.050539+00:00","id":8053,"links":{},"metadata":{"_buckets":{"deposit":"e5d7902c-d3a9-4304-a3f0-bd66426a96ac"},"_deposit":{"created_by":15,"id":"8053","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8053"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008053","sets":["334:627:1692670356714"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-03","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々はこれまでに、妊娠ラットにサリドマイドを投与することにより発症させた自閉症モデルラットにおいて、自閉症の特徴であるセロトニン神経系の異常、セロトニン神経の起始核である縫線核の異常や行動異常が起こることを明らかにしている。本研究では、この自閉症モデルラットにおいて、運動中枢である小脳に形態学的な異常があることを明らかにした。また脳（海馬、線条体）におけるモノアミン量の測定も行ったが、自閉症モデルラットと対照群の間に違いが見られなかった。","subitem_description_type":"Abstract"},{"subitem_description":"We have shown that \"\"our autism model rats\"\" which exposed to thalidomide during pregnancy impair serotonergic system including raphe nucleus and show behavior abnormality to the offspring. Now we have also shown that exposure to thalidomide during pregnancy induces morphological abnormalities in the cerebellum to the offspring. However, monoamine contents in the hippocampus and striatum did not differ between control group and thalidomide-treated group.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2011年度～2013年度科学研究費補助金(若手研究（B）)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"23791167","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Analysis of autism model rats exposed to thalidomide"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大河原, 剛","creatorNameLang":"ja"},{"creatorName":"OHKAWARA, Takeshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17550.pdf","filesize":[{"value":"352.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17550.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8053/files/30K17550.pdf"},"version_id":"439dbd22-5c59-418f-9f04-aa837167b170"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"自閉症","subitem_subject_scheme":"Other"},{"subitem_subject":"小脳","subitem_subject_scheme":"Other"},{"subitem_subject":"サリドマイド","subitem_subject_scheme":"Other"},{"subitem_subject":"モノアミン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"サリドマイド投与による自閉症モデルラットの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サリドマイド投与による自閉症モデルラットの解析","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670356714"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-01-15"},"publish_date":"2016-01-15","publish_status":"0","recid":"8053","relation_version_is_last":true,"title":["サリドマイド投与による自閉症モデルラットの解析"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:16:19.440329+00:00"}