{"created":"2023-06-19T11:39:51.432427+00:00","id":8062,"links":{},"metadata":{"_buckets":{"deposit":"ed450ce7-4a08-4232-aaa6-185170d623b3"},"_deposit":{"created_by":15,"id":"8062","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8062"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008062","sets":["334:627:1692670356714"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-21","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"移植系腫瘍モデルと異なり、3-MCA誘発腫瘍モデルにおいて、腫瘍が確認される２週間前前後から所属リンパ節の髄及び皮質内でIL-10とIL-17を産生するγδT細胞の異常増幅が観察された。この自然免疫型で免疫抑制性のγδT細胞増幅は、成熟CTL集団を含むCD107a+ CD8+ T細胞ばかりでなくCD4+ Foxp3+ Treg細胞のリンパ節からの流出阻止やアポトーシス誘導と直接関係することがわかった。抑制系γδT細胞増幅は、腫瘍と関連しないリンパ節でもある程度観察される。","subitem_description_type":"Abstract"},{"subitem_description":"IL-10- and IL-17-secreting gamma delta T cells expanded explosively in the medullaand subcapsular sinus of both draining and non-draining lymph nodes of subcutaneous 3-MCA-treated mice around two weeks before tumor formation. Abnormality of the innate IL-10+ IL-17+ gamma delta T cell expansion was demonstrated to be associated with the prevention of systemic circulation and the apoptosis induction of CD107a+ CD8+ mature CTLs and CD4+ Foxp3+ Treg cells in lymph nodes.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2013年度科学研究費補助金(研究活動スタート支援)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24800033","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Kinetics of suppressor T cells in spontaneous tumor-bearing mice"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"瀬尾, 尚宏","creatorNameLang":"ja"},{"creatorName":"SEO, Naohiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17505.pdf","filesize":[{"value":"181.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17505.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8062/files/30K17505.pdf"},"version_id":"7a25d88f-78d2-46f3-8f5e-d9a9803c0223"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"腫瘍所属リンパ節","subitem_subject_scheme":"Other"},{"subitem_subject":"γδT細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"キラーT細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"制御性T細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"抑制免疫細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫抑制","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自然発生腫瘍マウスにおける抑制性免疫動態に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自然発生腫瘍マウスにおける抑制性免疫動態に関する研究","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670356714"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-01-15"},"publish_date":"2016-01-15","publish_status":"0","recid":"8062","relation_version_is_last":true,"title":["自然発生腫瘍マウスにおける抑制性免疫動態に関する研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:16:38.001513+00:00"}