{"created":"2023-06-19T11:39:51.517179+00:00","id":8064,"links":{},"metadata":{"_buckets":{"deposit":"d617a61e-a788-41ff-a71d-394cd966864f"},"_deposit":{"created_by":15,"id":"8064","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8064"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008064","sets":["334:627:1692670356714"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-13","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高一回換気量の人工呼吸管理は人工呼吸器誘発肺傷害（Ventilator Induced Lung Injury, VILI）を引き起こす。本研究では、ラットでVILIを起こす換気条件で、NaHSによるVILI抑制作用について検討した。高一回換気量の人工呼吸換気条件では低一回換気量に比し、Evans Blueを指標とした肺血管透過性及び肺水分量は増加した。NaHSの一回と二回腹内投与実験では、肺水分量、Evans Blue、動脈血肺酸素化などに明らかな変化は見られなかった。一方、肺組織のIL-6、IL-1β、MCP1　mRNAの発現はNaHS投与によって低下傾向がみられた。","subitem_description_type":"Abstract"},{"subitem_description":"Ventilator induced lung injury (VILI) was caused by mechanical ventilation with high tidal volume. In this study, the mechanical ventilation conditions that caused VILI was demonstrated in rats. Inhibitory effect of VILI was investigated by administration of NaHS. The lung water content and protein permeability (Evans Blue) were increased in mechanical ventilation by high tidal volume (35ml/kg) compared with low tidal volume (6ml/kg). In both one time and two time administration of NaHS, the lung water content, Evans Blue and arterial oxygen pressure (PaO2) had no change in mechanical ventilation by high tidal volume. The mechanical ventilation with high tidal volume increased IL-6, IL-1, and MCP-1 mRNA expression, which had trend to decrease by administration of NaHS.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2011年度～2013年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"23592283","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Effects of hydrogen sulfide on ventilator induced lung injury"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"張, 尓泉","creatorNameLang":"ja"},{"creatorName":"Erquan, Zhang","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"丸山, 一男","creatorNameLang":"ja"},{"creatorName":"Maruyama, Kazuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"丸山, 淳子","creatorNameLang":"ja"}],"familyNames":[{"familyName":"Maruyama, Junko","familyNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17533.pdf","filesize":[{"value":"588.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17533.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8064/files/30K17533.pdf"},"version_id":"d09fc2ea-95cd-4382-b2aa-bcd9bfd96f20"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"人工呼吸器誘発肺傷害","subitem_subject_scheme":"Other"},{"subitem_subject":"硫化水素","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"人工呼吸器誘発肺傷害（ＶＩＬＩ）の硫化水素による治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"人工呼吸器誘発肺傷害（ＶＩＬＩ）の硫化水素による治療","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670356714"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-01-15"},"publish_date":"2016-01-15","publish_status":"0","recid":"8064","relation_version_is_last":true,"title":["人工呼吸器誘発肺傷害（ＶＩＬＩ）の硫化水素による治療"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:16:42.537732+00:00"}