{"created":"2023-06-19T11:39:51.603580+00:00","id":8066,"links":{},"metadata":{"_buckets":{"deposit":"eb0eccb1-5fde-438b-9c44-8bcf2ecf37fa"},"_deposit":{"created_by":15,"id":"8066","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8066"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008066","sets":["334:627:1692670356714"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"突発性難聴などの内耳疾患はストレスが一因と言われる。生理活性ペプチド・マンセリンはストレス呼応性で神経内分泌系を中心に発現している。これまでに研究代表者はマンセリンが内耳に存在することを見出した。マンセリンのストレス性内耳疾患への臨床応用を目指し、マンセリンの局在について発達およびストレス環境下での局在について検討した。マンセリンはラット内耳の有毛細胞シナプスとらせん神経節細胞、延髄蝸牛神経核、橋外側上オリーブ核と、聴覚伝達系に広く存在していた。ストレス負荷に伴い、内耳II型らせん神経節細胞の発現は減少した。よって、ストレス環境下でのマンセリンの聴覚伝達系制御への関与が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Inner ear disease such as sudden deafness and Meniere disease may be caused by stress. Manserin is distributed in the neuroendocrine system and its expression in the adrenal gland is stress dependent. Recently, I found the localization of manserin in the rat inner ear. In this study, I investigated the relationship between manserin and stress condition.Manserin localized at the neuronal terminals of the organ of Corti and spiral ganglion in the inner ear, cochlear nucleus in the medulla oblongata, and lateral superior olivary nucleus in the pons. Manserin immunoreactivity in the type II spiral ganglion cells was decreased by the stress. These results suggest that manserin may be involved in the regulation of auditory pathway under the stress condition.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2011年度～2013年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"23791891","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Involvement of neuropeptide to the stress-related inner ear diseases"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"江藤, みちる","creatorNameLang":"ja"},{"creatorName":"IDA-ETO, MICHIRU","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"(伊田, みちる)","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17551.pdf","filesize":[{"value":"282.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17551.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8066/files/30K17551.pdf"},"version_id":"3c54eb5c-4aad-4731-9e51-7e8ce0b212a5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"内耳","subitem_subject_scheme":"Other"},{"subitem_subject":"神経ペプチド","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ストレス性内耳疾患の病態解明と臨床への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ストレス性内耳疾患の病態解明と臨床への応用","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670356714"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-01-15"},"publish_date":"2016-01-15","publish_status":"0","recid":"8066","relation_version_is_last":true,"title":["ストレス性内耳疾患の病態解明と臨床への応用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:16:47.520919+00:00"}