{"created":"2023-06-19T11:39:51.904455+00:00","id":8073,"links":{},"metadata":{"_buckets":{"deposit":"f9134389-3411-4c1a-9224-bb3d18498f45"},"_deposit":{"created_by":15,"id":"8073","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8073"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008073","sets":["334:627:1692670376097"]},"author_link":["19811"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"１才半以降に発症する神経芽腫の予後は不良であり、新しい治療法の開発が望まれている。これまで我々は、in vitroとin vivoの実験により、ポリオウイルス（PV）は神経芽腫に対し強い抗腫瘍効果をもち、さらにPVにより神経芽腫が治癒したマウスには、神経芽腫に対する抗腫瘍免疫が誘導されることを証明してきた。これらの基礎実験を踏まえ、三重大学病院では再発・難治性神経芽腫の患者さんを対象に、PVによる神経芽腫の第１相臨床試験を開始し、現在まで２名の患者さんの治療を行った。","subitem_description_type":"Abstract"},{"subitem_description":"The prognosis of neuroblastoma patients is poor. Thus, to develop a novel treatment is necessary. Our previous studies show that poliovirus has strong anti-neuroblastoma effects both in vitro and in vivo, and anti-neuroblastoma immune response was induced in neuroblastoma cured mice. In accordance with these findings, we started phase 1 clinical trial for relapse and refractory neuroblastoma patients. We have treated two relapsed neuroblastoma patients so far.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24591547","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"novel treatment for neuroblastoma by live-attenuated poliovirus"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"豊田, 秀実","creatorNameLang":"ja"},{"creatorName":"TOYODA, Hidemi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17878.pdf","filesize":[{"value":"289.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17878.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8073/files/30K17878.pdf"},"version_id":"b332ed7c-6c6a-4a5d-a911-ad2861a0a20b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経芽腫","subitem_subject_scheme":"Other"},{"subitem_subject":"ポリオウイルス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"弱毒ポリオウイルスを用いた神経芽腫の新しい治療法の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"弱毒ポリオウイルスを用いた神経芽腫の新しい治療法の研究","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670376097"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8073","relation_version_is_last":true,"title":["弱毒ポリオウイルスを用いた神経芽腫の新しい治療法の研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:40:09.615318+00:00"}