{"created":"2023-06-19T11:39:52.029684+00:00","id":8076,"links":{},"metadata":{"_buckets":{"deposit":"cc6fab5c-005c-4923-8916-f947b7e57a56"},"_deposit":{"created_by":15,"id":"8076","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8076"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008076","sets":["334:627:1692670376097"]},"author_link":["19825","19826"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は当研究室で独自に樹立した遺伝子改変マウスを用いて造血細胞において特定の時期にMLL-ENLキメラ遺伝子を誘導発現することによって白血病幹細胞を発生させ、白血病発症の分子機構を探ることを目的とする。MLL-ENLの発現だけでは、胎仔肝細胞から白血病はできにくく、成獣骨髄細胞の方ができやすかった。さらに、白血病細胞が生じる際には、胚性幹細胞の自己複製において重要な役割を担うTet1と呼ばれる遺伝子が、がん化には抑制的に働いているらしい所見が得られた。","subitem_description_type":"Abstract"},{"subitem_description":"The goal of this study is to clarify the molecular mechanism for generation of leukemic stem cells by using the inducible MLL-ENL transgenic mice which we made. The efficiency of immortalization of fetal liver cells was lower than that of adult bone marrow cells when MLL-ENL was inducibly expressed. In addition, we found that Tet1 which is known to be involved in self renewal of embryonic stem cells, negatively regulates the leukemogenesis in this model system.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(挑戦的萌芽研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24659494","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Model for generation of leukemic stem cells : spatio-temporal properties in pathogenesis"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野阪, 哲哉","creatorNameLang":"ja"},{"creatorName":"NOSAKA, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小埜, 良一","creatorNameLang":"ja"},{"creatorName":"ONO, Ryoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19826","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17896.pdf","filesize":[{"value":"152.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17896.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8076/files/30K17896.pdf"},"version_id":"65512de4-843c-4e20-96fb-01bdd1834977"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"白血病","subitem_subject_scheme":"Other"},{"subitem_subject":"白血病幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ＭＬＬ","subitem_subject_scheme":"Other"},{"subitem_subject":"ＭＬＬ－ＥＮＬ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"時空特異的白血病幹細胞発生モデルと病態特性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"時空特異的白血病幹細胞発生モデルと病態特性","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670376097"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8076","relation_version_is_last":true,"title":["時空特異的白血病幹細胞発生モデルと病態特性"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:40:18.300918+00:00"}