{"created":"2023-06-19T11:39:52.071397+00:00","id":8077,"links":{},"metadata":{"_buckets":{"deposit":"caf8982e-5700-4763-a941-8253ebd9f1c1"},"_deposit":{"created_by":15,"id":"8077","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8077"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008077","sets":["334:627:1692670376097"]},"author_link":["19829","19830"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-20","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(1) マウス型CEA特異的CARレトロウイルスベクターコンストラクトの作成とマウスT細胞への導入 (2) マウス型CAR導入マウスＴ細胞のin vitro機能評価。(3)リンパ球減少性の前処置との併用によりCEA特異的CAR導入T細胞輸注は、抗腫瘍効果を発揮した。(4) 輸注したCAR-TはWTとCEA－Tgマウスにおいて同程度の抗腫瘍効果を発揮したが、CEA-Tgマウスにのみ重篤な体重減少を誘導した。(5) CAR-T輸注によりWTとCEA-Tgマウスの肺に炎症が見られた。(6) CEAを標的としたCAR導入T細胞輸注療法は有効だが、安全性に十分な注意を払う必要性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"(1)Retrovirus vector composed of anti-CEA scFV and signaling domain of human or mouse CD3 and CD28 successfully transduced human or mouse T cells, respectively, to express functional CAR. (2) Adoptive therapy with CEA-specific CAR expressing human T cells to tumor bearing lymphopenic NOG mouse inhibited growth of CEA positive, but not CEA negative, tumor. (3) Likewise, adoptive therapy with CEA-specific CAR expressing mouse T cells to tumor bearing lymphoreplete CEA-Tg mouse inhibited growth of CEA-positive tumor only when the mouse received lymphodepleting preconditioning. (4) However, this tumor growth inhibition was associated with inflammation in lungs in a manner independent of CAR-specificity and severe weight loss in a manner dependent of CAR-specificity. (5) CEA-specific CAR-T cells induce systemic cytokine response that could induce anorexia in CEA-Tg. (6) CEA-specific CAR-T cells induce malnutrition in CEA-Tg.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24591899","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"EFFICACY AND SAFETY OF T CELLS WITH CEA-SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR CANCER IMMUNOTHERAPY"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"王, 立楠","creatorNameLang":"ja"},{"creatorName":"WANG, Linan","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 琢磨","creatorNameLang":"ja"},{"creatorName":"KATO, Takuma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19830","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17881.pdf","filesize":[{"value":"167.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17881.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8077/files/30K17881.pdf"},"version_id":"da64b3ec-5d02-4bf5-97a8-9c1adc5e62f7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CEA-Tgマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"CAR-T細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌胎児性抗原特異的キメラ抗原受容体導入Ｔ細胞による消化器癌治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌胎児性抗原特異的キメラ抗原受容体導入Ｔ細胞による消化器癌治療法の開発","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670376097"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8077","relation_version_is_last":true,"title":["癌胎児性抗原特異的キメラ抗原受容体導入Ｔ細胞による消化器癌治療法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:40:19.679967+00:00"}