{"created":"2023-06-19T11:39:52.113432+00:00","id":8078,"links":{},"metadata":{"_buckets":{"deposit":"56a91851-77dc-4e0f-9ffb-82054131331b"},"_deposit":{"created_by":15,"id":"8078","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8078"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008078","sets":["334:627:1692670376097"]},"author_link":["19833","19834"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-20","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"スギ花粉皮膚炎(CPD)の病態解析と治療開発のためCPDモデルマウスの作成を行った。日本スギ花粉(JCP)抗原の非経皮感作と経皮感作を併用し一部のマウスで感作が成立し、感作動物のリンパ系細胞ならびに皮膚のサイトカインFACS解析を行った。しかし、マウスへの感作の頻度は低く実用性が問題となった。そこでヒトCPDを模倣し、経鼻的感作による花粉症モデルを成立させ､引き続き経皮感作を行うCPDモデルを目指した。長期の経鼻感作により効率のよいTh2型花粉症マウスの作成に成功した。その解析と治療開発を進めると共に、経皮感作によるCPDモデルマウスの樹立を進めている。","subitem_description_type":"Abstract"},{"subitem_description":"We tried development of a mouse model for the Japanese cedar pollen dermatitis (CPD). Immunization with combination of the percutaneous and non-percutaneous application with Japanese cedar pollen antigens successfully sensitized some mice. FACS analysis of the lymphocytes and the skin cytokine mRNA profile of the immunized mouse revealed sensitization in some mouse. However, we have to change the strategy because of the very low sensitization efficiency of this model. Following to human Japanese cedar pollinosis (JCP), we developed a mouse model for JCP by repeated trans-nasal immunization, and successfully developed a Th2 type JCP mouse model. We are analyzing the immunological profile of the JCP model and are developing the CPD model by additional immunization.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24591647","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Investigation of the mechanism and therapy for Japanese cedar pollen dermatitis"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水谷, 仁","creatorNameLang":"ja"},{"creatorName":"MIZUTANI, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山中, 恵一","creatorNameLang":"ja"},{"creatorName":"YAMANAKA, Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17880.pdf","filesize":[{"value":"162.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17880.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8078/files/30K17880.pdf"},"version_id":"7d04f368-5e6e-4c1d-ad71-702567ac2796"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"花粉皮膚炎","subitem_subject_scheme":"Other"},{"subitem_subject":"スギ花粉症","subitem_subject_scheme":"Other"},{"subitem_subject":"アレルギー","subitem_subject_scheme":"Other"},{"subitem_subject":"アトピー性皮膚炎","subitem_subject_scheme":"Other"},{"subitem_subject":"アレルギー性鼻炎","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"花粉症皮膚炎の病態解明と抑制性細胞誘導による治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"花粉症皮膚炎の病態解明と抑制性細胞誘導による治療","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670376097"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8078","relation_version_is_last":true,"title":["花粉症皮膚炎の病態解明と抑制性細胞誘導による治療"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:40:22.738355+00:00"}