{"created":"2023-06-19T11:39:52.285000+00:00","id":8082,"links":{},"metadata":{"_buckets":{"deposit":"1bfdcc75-c8ca-40c8-a268-681876e2de66"},"_deposit":{"created_by":15,"id":"8082","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8082"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008082","sets":["334:627:1692670376097"]},"author_link":["19869","19870"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-27","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"筋萎縮性側索硬化症(ALS)は、運動ニューロンが選択的かつ進行性に変性・消失していく原因不明の疾患であり、初期に確実に診断できる特異的検査法もない。本研究では、ALS患者の脳脊髄液中のタンパク質や代謝産物の変動解析を行った。その結果、セロトランスフェリンなどがALS患者群の脳脊髄液で有意に増加し、酸化損傷も受けていた。これらのタンパク質はALSの発症に関与し、また疾患バイオマーカーとなる可能性がある。","subitem_description_type":"Abstract"},{"subitem_description":"Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive degeneration of the upper and lower motor neurons, which results in paralysis of the limbs and/or the bulbar musculature. However, because there are no specific biomarkers for ALS, it is difficult to diagnose this disease at early stages. Therefore, we compared the protein profile in cerebrospinal fluids (CSF) of ALS patients and control subjects by two-dimensional differential in-gel electrophoretic analysis (2D DIGE) and two-dimensional gel electrophoresis with immunochemical detection of protein carbonyls (2D Oxyblot). We showed that 4 proteins (serotransferrin, etc) were increased in CSF of ALS patients compared with control subjects. In addition, we found that carbonyl modification of pigment epithelium-derived factor, serotransferrin, and so forth was increased in CSF of ALS patients. This study presumes some of these proteins could be candidates of biomarkers for ALS.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(挑戦的萌芽研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24659300","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"A study on the pathogenic mechanism of amyotrophic lateral sclerosis (ALS) and search for efficient biomarkers using proteomic/metabolomic analysis"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"及川, 伸二","creatorNameLang":"ja"},{"creatorName":"OIKAWA, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19869","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"冨本, 秀和","creatorNameLang":"ja"},{"creatorName":"TOMIMOTO, Hidekazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19870","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17895.pdf","filesize":[{"value":"315.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17895.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8082/files/30K17895.pdf"},"version_id":"99e5d1cc-cf2f-4b0c-a893-ee3e33a245e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"筋萎縮性側索硬化症","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"脳脊髄液","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテオーム","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"},{"subitem_subject":"カルボニル化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"プロテオーム・メタボローム解析を用いたＡＬＳ発症機構の解明とバイオマーカーの探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プロテオーム・メタボローム解析を用いたＡＬＳ発症機構の解明とバイオマーカーの探索","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670376097"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8082","relation_version_is_last":true,"title":["プロテオーム・メタボローム解析を用いたＡＬＳ発症機構の解明とバイオマーカーの探索"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:40:32.463397+00:00"}