{"created":"2023-06-19T11:39:52.374055+00:00","id":8084,"links":{},"metadata":{"_buckets":{"deposit":"69589ae6-6f28-42b9-a0dc-0e473eb38e85"},"_deposit":{"created_by":15,"id":"8084","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8084"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008084","sets":["334:627:1692670376097"]},"author_link":["19875","19876"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-18","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、白血病発症と密接に関連するエピゲノム異常に着目し、その制御分子の一つについて、条件的遺伝子欠損マウスを作製し、白血病発症マウスモデルと組み合わせた異常造血の解析や正常造血系の解析を行った。その結果、標的分子の条件的欠損を誘導したところ、白血病発症に関する決定的影響は見出されていないものの、造血幹細胞の自己複製や分化に関する興味深い知見が見出され、現在、詳細な分子生物学的解析を進めている","subitem_description_type":"Abstract"},{"subitem_description":"In this study, to focus on epigenetic alterations closely associated with leukemogenesis, I have generated conditional knockout mice of an epigenome regulator, analyzed malignant hematopoiesis of these mice combined with my leukemogenic mouse model, and characterized normal hematopoiesis of the mice. Conditional ablation of the target molecule induced no critical phenotypic changes in leukemogenesis, but led to interesting findings concerning self-renewal and differentiation of hematopoietic stem cells. I am further investigating the molecular mechanisms at the moment.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24591390","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Analysis of molecular mechanism in leukemogenesis through an epigenome regulator"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小埜, 良一","creatorNameLang":"ja"},{"creatorName":"ONO, Ryoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19875","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野阪, 哲哉","creatorNameLang":"ja"},{"creatorName":"NOSAKA, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19876","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17876.pdf","filesize":[{"value":"359.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17876.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8084/files/30K17876.pdf"},"version_id":"73a534fb-a8e8-4d4b-85c0-d4569415c7e0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"白血病","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"エピゲノム制御分子を介した白血病の分子病態の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エピゲノム制御分子を介した白血病の分子病態の解明","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670376097"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8084","relation_version_is_last":true,"title":["エピゲノム制御分子を介した白血病の分子病態の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:40:37.222775+00:00"}