{"created":"2023-06-19T11:39:52.464005+00:00","id":8086,"links":{},"metadata":{"_buckets":{"deposit":"04b50bad-c3f9-46ae-ad99-3296cf999c4a"},"_deposit":{"created_by":15,"id":"8086","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8086"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008086","sets":["334:627:1692670376097"]},"author_link":["19887"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳動脈瘤コイル塞栓術後の再開通予防を目的に、テネイシンC担持硫酸化ジェラン加工糸プラチナコイルを作成し、ウサギエラスターゼ動脈瘤モデルを用いて、実際の血管内治療に即した方法で、コイル塞栓術を行った。その結果、テネイシンC担持硫酸化ジェラン加工糸プラチナコイルは、通常用いられるプラチナコイルよりも、動脈瘤頚部の新生内膜の形成、瘤内の器質化促進作用が有ることが分かった。さらにそのメカニズムに、TGF―β、テネイシンC、MMP-9が関連することも分かった。","subitem_description_type":"Abstract"},{"subitem_description":"We conduct this study for the aim of evaluating the effects of Gellan sulfate core platinum coil (GSCC) with tenascin-C (TNC) (GSCC-TNC). Elastase-induced rabbit aneurysms were randomly coiled with platinum coils (PCs), GSCCs or GSCC-TNCs and aneurysm-occlusion status was evaluated at 2 weeks post-coiling. In addition, a PC, GSCC or GSCC-TNC was randomly implanted in a rat blind-ended model and the organization effects were immunohistochemically evaluated for expressions of TNC, transforming growth factor-beta (TGF-β) and matrix metalloproteinase-9 (MMP-9) 2 weeks later. As a result, GSCCs showed a significantly higher ratio of organized area to the aneurysmal cavity than PCs. GSCC-TNCs had intense immunoreactivities for TNC, TGF-β and MMP-9 in the organized thrombosis and tunica media. GSCC-TNCs demonstrated potent aneurysm repair effects in a simulated clinical setting using rabbits possibly through the TGF-β and MMP-9 upregulation.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24592122","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Development of gellan sulfate core platinum coil with bioactive substances"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松島, 聡","creatorNameLang":"ja"},{"creatorName":"MATSUSHIMA, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19887","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17884.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17884.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8086/files/30K17884.pdf"},"version_id":"72f6506c-0a94-4d00-8616-64110ced1783"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脳動脈瘤","subitem_subject_scheme":"Other"},{"subitem_subject":"脳血管内治療","subitem_subject_scheme":"Other"},{"subitem_subject":"生理活性","subitem_subject_scheme":"Other"},{"subitem_subject":"コイル","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"硫酸化ジェラン線維性素材を用いた生理活性コイルの開発研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"硫酸化ジェラン線維性素材を用いた生理活性コイルの開発研究","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670376097"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8086","relation_version_is_last":true,"title":["硫酸化ジェラン線維性素材を用いた生理活性コイルの開発研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:40:40.938974+00:00"}