{"created":"2023-06-19T11:39:52.509399+00:00","id":8087,"links":{},"metadata":{"_buckets":{"deposit":"d818daf5-8a37-4c79-9a3d-5709accc458c"},"_deposit":{"created_by":15,"id":"8087","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8087"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008087","sets":["334:627:1692670376097"]},"author_link":["19889","19890","19891"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"繊維・粒子状物質の吸入曝露は呼吸器の発がんや線維化を起こすが、その機構には不明な点が多い。本課題では、石綿やインジウム化合物を気管内投与した動物の肺組織におけるマイクロRNA(miRNA)と遺伝子の発現をマイクロアレイで網羅的に解析した。その結果、多数のmiRNAの発現量が有意に変動し、発がんや線維化に関わる遺伝子を制御する可能性を明らかにした。インジウム化合物に曝露したラットの血清でも有意に存在量が変動するmiRNAを認めた。miRNAはこれらの物質の曝露を受けた個人の呼吸器疾患のリスク評価指標になりうると考えられ、インジウム曝露者を対象とした分子疫学研究への応用につながる知見が得られた。","subitem_description_type":"Abstract"},{"subitem_description":"Inhalation exposure to fibrous and particlate materials induces carcinogenesis and fibrosis in respiratory systems, but precise mechanisms remain to be clarified. We have performed comprehensive microarray analysis for microRNA (miRNA) and gene expression in the lung tissues of animals exposed to asbestos and indium compounds. We found that these compounds significanlty changed the expression levels of several miRNAs, which may regulate genes involved in carcinogenesis and fibrosis. We also found that an indium compound altered miRNA levels in the serum of rats. These findings raise the possibility that miRNAs can be used for evaluation of the risk of respiratory diseases in individuals exposed to these compounds and provide an insight into molecular epidemiology for indium-exposed workers.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(基盤研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24390153","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"MicroRNA-based risk assessment for fibrous and particulate substances on the basis of molecular epidemiological and experimental studies"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平工, 雄介","creatorNameLang":"ja"},{"creatorName":"HIRAKU, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大前, 和幸","creatorNameLang":"ja"},{"creatorName":"OMAE, Kazuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 昭代","creatorNameLang":"ja"},{"creatorName":"TANAKA, Akiyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19891","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17946.pdf","filesize":[{"value":"490.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17946.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8087/files/30K17946.pdf"},"version_id":"971fdbba-0d61-4138-b312-55a34eddefc7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"繊維・粒子状物質","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"インジウム","subitem_subject_scheme":"Other"},{"subitem_subject":"石綿","subitem_subject_scheme":"Other"},{"subitem_subject":"発がん","subitem_subject_scheme":"Other"},{"subitem_subject":"リスク評価","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マイクロＲＮＡを指標とする分子疫学と実験研究に基づく繊維・粒子状物質のリスク評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マイクロＲＮＡを指標とする分子疫学と実験研究に基づく繊維・粒子状物質のリスク評価","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670376097"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8087","relation_version_is_last":true,"title":["マイクロＲＮＡを指標とする分子疫学と実験研究に基づく繊維・粒子状物質のリスク評価"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:40:43.284190+00:00"}