@techreport{oai:mie-u.repo.nii.ac.jp:00008090,
 author = {山崎, 英俊 and YAMAZAKI, Hidetoshi and 山根, 利之 and YAMANE, Toshiyuki},
 month = {Jun},
 note = {application/pdf, 中胚葉或いは神経堤由来細胞を蛍光標識し、かつジフテリアトキシン受容体(DTR)を発現し、DT投与により中胚葉或は神経堤由来細胞を欠損させることの出来るマウスを用いて、神経堤或は中胚葉に由来する細胞を欠損させると胸腺及び骨髄の造血に異常が見られる事を明らかにした。神経堤由来細胞は間葉のみならず、自律神経や副腎髄質にも寄与し、神経堤欠損マウスでは、血中のアドレナリンやノルアドレナリンが減少し、これが造血異常の原因である可能性が示唆された。新生仔マウス歯髄間葉が骨髄間葉同様にB細胞や破骨細胞の分化支持能を持つ事を見いだしたが、胎仔歯髄には胎仔骨髄同様の造血器官形成能や造血支持能は確認できなかった。, By using Cre-LoxP mediated transgenic mice that have NC- or mesoderm-specific Cre expression and Cre-activated YFP reporter and Diphtheria Toxin (DT) Receptor, NC- or mesoderm-derived cells were depleted by the administration of DT. The consequence of DT-mediated depletion of these cells on B and T lymphopoiesis was examined by flowcytometry. Severe reduction of the number of B and T cell progenitors in the BM and thymus was observed by the depletion. As NC cells contributed to sympathetic neurons, to investigate the affect of sympathetic neurons in DT-administrated mice, concentrations of catechoramin were measured in plasma, and those of noradrenalin and adrenalin were significantly reduced. These results suggest that NC-derived mesenchyme and sympathetic neurons are involved in B and T lymphopoiesis. Although dental mesenchyme supported B lymphopoiesis and osteoclastogenesis as well as bone marrow, embryonic tooth mesenchyme had little hematopoietic supporting capacity., 2012年度～2014年度科学研究費補助金(挑戦的萌芽研究)研究成果報告書, 24659811},
 title = {造血系疾患の治療を目指した歯髄、骨髄の神経堤及び中胚葉由来間葉の造血支持能の研究},
 year = {2015}
}