{"created":"2023-06-19T11:39:52.731295+00:00","id":8092,"links":{},"metadata":{"_buckets":{"deposit":"e2e7e853-204a-4b13-aa6d-1cec939fdb17"},"_deposit":{"created_by":15,"id":"8092","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8092"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008092","sets":["334:627:1692670376097"]},"author_link":["19905","19906","19907"],"control_number":"8092","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-20","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では全身にヒトmetalloproteinase-(MMP-)2を発現するトランジェニック（TG）マウスを作製し、タバコ煙抽出物の吸引投与により、3週間程度の短期間で慢性閉塞性肺患(COPD)を高い確率で発症することが確認できた。本TGマウスを用いることにより、COPDに関する研究を飛躍的に発展させられる。また、本研究では、COPDの発症に及ぼすNF-kappaB siRNAの吸入の効果を検討した。その結果、非投与のMMP-2 TGマウス群に比べ、NF-kappaB siRNAを投与したTGマウス群では気管支肺洗浄液中の総細胞数、肺組織中の炎症性サイトカインの発現が有意に高値を示した。","subitem_description_type":"Abstract"},{"subitem_description":"In the present research project, we developed a novel metalloproteinase-(MMP-)2 transgenic mouse that showed characteristic findings of chronic obstructive pulmonary disease (COPD) after short-term exposure to inhaled cigarette smoke extracts. Wild type mice usually required exposure to cigarette smoke extracts of more than half-a-year to develop COPD typical findings in the lungs. In addition, this study evaluated the therapeutic usefulness of NF-kappaB siRNA in COPD using our present mouse model. Compared to control, intranasal administration of NF-kappaB siRNA significantly suppressed lung pathological changes, cell inflammation and inflammatory cytokines. The results of this study suggest the potential therapeutic usefulness of siRNA against NF-kappaB signal pathways in COPD.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24591128","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Development of new therapeutic strategies for chronic obstructive diseases using RNA interference"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"GABAZZA, Esteban","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小林, 哲","creatorNameLang":"ja"},{"creatorName":"KOBAYASHI, Tetsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MORSER, John","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"30K17875.pdf","filesize":[{"value":"391.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K17875.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8092/files/30K17875.pdf"},"version_id":"a1dbe24e-0c25-4393-9699-bb1177c9f921"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺気腫","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内伝達機構","subitem_subject_scheme":"Other"},{"subitem_subject":"NF-kappaB","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA干渉","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテアーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"MMP-2","subitem_subject_scheme":"Other"},{"subitem_subject":"煙草","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性サイトカイン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ＲＮＡ干渉を応用した慢性閉塞性疾患の新規治療戦略の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ＲＮＡ干渉を応用した慢性閉塞性疾患の新規治療戦略の開発","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692670376097"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8092","relation_version_is_last":true,"title":["ＲＮＡ干渉を応用した慢性閉塞性疾患の新規治療戦略の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-07T04:48:17.089900+00:00"}