{"created":"2023-06-19T11:39:52.944829+00:00","id":8097,"links":{},"metadata":{"_buckets":{"deposit":"2374c3e8-c712-4238-9e84-a77f799a138f"},"_deposit":{"created_by":15,"id":"8097","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8097"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008097","sets":["631:632:633"]},"author_link":["19938","19939","19940","19941","19942","19943","19944","19945","19946","19947","19948","19949"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"265487","bibliographicVolumeNumber":"2012","bibliographic_titles":[{"bibliographic_title":"Journal of oncology"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In vivo real-time visualization of the process of angiogenesis in secondary tumors in the same living animals presents a major\nchallenge in metastasis research.We developed a technique for intravital imaging of colorectal liver metastasis development in live\nmice using two-photon laser scanning microscopy (TPLSM). We also developed time-series TPLSM in which intravital TPLSM\nprocedures were performed several times over periods of days to months. Red fluorescent protein-expressing colorectal cancer cells\nwere inoculated into the spleens of green fluorescent protein-expressing mice. First- and second-round intravital TPLSM allowed\nvisualization of viable cancer cells (red) in hepatic sinusoids or the space of Disse. Third-round intravital TPLSM demonstrated\nliver metastatic colonies consisting of viable cancer cells and surrounding stroma with tumor vessels (green). In vivo time-course\nimaging of tumor angiogenesis in the same living mice using time-series TPLSM could be an ideal tool for antiangiogenic drug\nevaluation, reducing the effects of interindividual variation.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi Publishing Corporation"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1687-8469","subitem_source_identifier_type":"PISSN"}]},"item_10001_text_70":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Journal Article / 学術雑誌論文"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morimoto, Yuhki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushita, Kohei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawamura, Mikio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koike, Yuhki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okugawa, Yoshinaga","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchida, Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Araki, Toshimitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizoguchi, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39A15352.pdf","filesize":[{"value":"4.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39A15352.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8097/files/39A15352.pdf"},"version_id":"733669de-c305-487b-beeb-91edbf00d9e9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In vivo time-course imaging of tumor angiogenesis in colorectal liver metastases in the same living mice using two-photon laser scanning microscopy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo time-course imaging of tumor angiogenesis in colorectal liver metastases in the same living mice using two-photon laser scanning microscopy","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["633"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-12-15"},"publish_date":"2011-12-15","publish_status":"0","recid":"8097","relation_version_is_last":true,"title":["In vivo time-course imaging of tumor angiogenesis in colorectal liver metastases in the same living mice using two-photon laser scanning microscopy"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-10-12T03:00:43.542969+00:00"}