{"created":"2023-06-19T11:39:53.069841+00:00","id":8100,"links":{},"metadata":{"_buckets":{"deposit":"0f53c33b-f3bb-437b-9a02-80d358771bd5"},"_deposit":{"created_by":15,"id":"8100","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8100"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008100","sets":["631:632:633"]},"author_link":["19966","19967","19968","19969","19970","19971","19972","19973","19974","19975"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"62","bibliographicPageStart":"55","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Annals of transplantation : quarterly of the Polish Transplantation Society"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The impact of cytochrome P450 3A5 (CYP3A5) genotype of recipients (intestine)\nas well as donors (graft liver) on the tacrolimus pharmacokinetics and the\nincidence of infectious complications was assessed in Japanese living-donor liver\ntransplant (LDLT) adult recipients.\nMaterial/Methods: Fifty-six patients were divided into 4 groups based on the CYP3A5 genotype (expression\nof *1 allele: expressor (EX) and non-expressor (NEX)) in each recipients\n(R) and donors (D), EX-R/EX-D (n=9), EX-R/NEX-D (n=7), NEX-R/EX-D\n(n=12) and NEX-R/NEX-D (n=28). Tacrolimus blood concentration and concentration/\ndosage ratio (C/D) were evaluated every week until 4 weeks and every\nmonth until 12 months after LDLT. The incidences of postoperative infectious\ncomplication, acute cellular rejection and tacrolimus adverse effect were\ncompared.\nResults: The tacrolimus blood concentrations among 4 groups did not significantly differ\nat each follow-up time period. The C/Ds were significantly lower in EX-R/EX-D\n(median: 122.3 at 2 weeks) than in NEX-R/NEX-D (389.6 at 2 weeks) until 12\nmonths. The C/Ds in EX-R/NEX-D (163.2 at 2 weeks) have been significantly\nlower than those in NEX-R/NEX-D until 6 months. Over 6 months, however,\nthose in NEX-R/EX-D showed lower levels (84.1 at 8 months) than those in\nNEX-R/NEX-D (189.3 at 8 months). Additionally, logistic regression analysis\nshowed that EX-R/EX-D had significantly higher risk for the development of infectious\ncomplications than NEX-R/NEX-D (odds ratio 8.67, p=0.03).\nConclusions: Preoperative assessment of CYP3A5 genotypes in both recipients and donors\nwould be useful not only for predicting tacrolimus pharmacokinetics but also\ndefining high-risk group of infectious complications after LDLT.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Scientific Literature"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1425-9524","subitem_source_identifier_type":"PISSN"}]},"item_10001_text_70":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Journal Article / 学術雑誌論文"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muraki, Yuichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui, Masanobu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isaji, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizuno, Shugo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakatani, Kaname","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Tomomi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwamoto, Takuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uemoto, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nobori, Tsutomu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okuda, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39A15524.pdf","filesize":[{"value":"184.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39A15524.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8100/files/39A15524.pdf"},"version_id":"5846d6ae-c7f1-48bc-92bd-6718e87cbc02"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CYP3A5","subitem_subject_scheme":"Other"},{"subitem_subject":"single nucleotide polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"tacrolimus","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"liver transplantation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["633"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-03-27"},"publish_date":"2013-03-27","publish_status":"0","recid":"8100","relation_version_is_last":true,"title":["Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-10-12T03:00:55.636416+00:00"}